Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Ken Cham Fai Leung; Chun Pong Chak; Siu Fung Lee; Josie M.Y. Lai; Xiao Ming Zhu; Yi Xiang J. Wang; Kathy W.Y. Sham; Christopher H.K. Cheng

doi:10.1039/c2cc36663k

Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Ken Cham Fai Leung^*, Chun Pong Chak, Siu Fung Lee, Josie M.Y. Lai, Xiao Ming Zhu, Yi Xiang J. Wang, Kathy W.Y. Sham, Christopher H.K. Cheng

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

18 Citations (Scopus)

Abstract

Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

Original language	English
Pages (from-to)	549-551
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	6
DOIs	https://doi.org/10.1039/c2cc36663k
Publication status	Published - 2013

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c2cc36663k

Cite this

@article{746280751db947bfbb741495ee892f1c,

title = "Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites",

abstract = "Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.",

author = "Leung, {Ken Cham Fai} and Chak, {Chun Pong} and Lee, {Siu Fung} and Lai, {Josie M.Y.} and Zhu, {Xiao Ming} and Wang, {Yi Xiang J.} and Sham, {Kathy W.Y.} and Cheng, {Christopher H.K.}",

year = "2013",

doi = "10.1039/c2cc36663k",

language = "English",

volume = "49",

pages = "549--551",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "6",

}

TY - JOUR

T1 - Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

AU - Leung, Ken Cham Fai

AU - Chak, Chun Pong

AU - Lee, Siu Fung

AU - Lai, Josie M.Y.

AU - Zhu, Xiao Ming

AU - Wang, Yi Xiang J.

AU - Sham, Kathy W.Y.

AU - Cheng, Christopher H.K.

PY - 2013

Y1 - 2013

N2 - Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

AB - Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

UR - http://www.scopus.com/inward/record.url?scp=84871258613&partnerID=8YFLogxK

U2 - 10.1039/c2cc36663k

DO - 10.1039/c2cc36663k

M3 - Journal article

C2 - 23192002

AN - SCOPUS:84871258613

SN - 1359-7345

VL - 49

SP - 549

EP - 551

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Abstract

Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this