Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Ken C F LEUNG*, Chun Pong Chak, Siu Fung Lee, Josie M.Y. Lai, Xiao Ming Zhu, Yi Xiang J. Wang, Kathy W.Y. Sham, Christopher H.K. Cheng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

Original languageEnglish
Pages (from-to)549-551
Number of pages3
JournalChemical Communications
Volume49
Issue number6
DOIs
Publication statusPublished - 2013

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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