Engineering of Single Magnetic Particle Carrier for Living Brain Cell Imaging: A Tunable T1-/T2-/Dual-Modal Contrast Agent for Magnetic Resonance Imaging Application

Yung Kang Peng, Cathy N.P. Lui, Yu Wei Chen, Shang Wei Chou, Elizabeth Raine, Pi Tai Chou, Kin Lam YUNG*, S. C.Edman Tsang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Despite a variety of T1-T2 dual-modal contrast agents (DMCAs) reported for magnetic resonance imaging (MRI), no tuning of local induced magnetic field strength of an DMCA, which is important to modulate the overall T1 and T2 responses for imaging delicate cells, tissues, and organs, is yet available. Here, we show that a spatial arrangement of T1 and T2 components within a "nano zone" in a single core-shell nanoparticle carrier (i.e., DMCA with core Fe3O4 and MnO clusters in a silica shell) to produce the necessary fine-tuning effect. It is demonstrated that this particle after the anti-CD133 antibody immobilization allows both T1 and T2 imaging at higher resolution for living ependynmal brain cells of rodents with no local damage under a strong MRI magnetic field. This study opens a route to rational engineering of DMCAs for accurate magnetic manipulations in a safe manner.

Original languageEnglish
Pages (from-to)4411-4417
Number of pages7
JournalChemistry of Materials
Volume29
Issue number10
DOIs
Publication statusPublished - 23 May 2017

Scopus Subject Areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

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