Abstract
Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localisation (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T 2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent for neural stem cells (NSCs) imaging and magnetic manipulation in live rodents. As a result, using this engineered nanoparticle and associated technologies, identification, stimulation and transportation of labelled potentially multipotent NSCs from a specific location of a live brain to another by magnetic means for self-healing therapy can therefore be made possible.
Original language | English |
---|---|
Article number | 015102 |
Journal | Nanotechnology |
Volume | 29 |
Issue number | 1 |
Early online date | 4 Dec 2017 |
DOIs | |
Publication status | Published - 5 Jan 2018 |
Scopus Subject Areas
- Bioengineering
- Chemistry(all)
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
- Electrical and Electronic Engineering
User-Defined Keywords
- cell harvesting
- Magnetic field engineering
- neural stem cells
- safe magnetic manipulation
- T1-T2 dual MR imaging