Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents

Yung Kang Peng; Cathy N.P. Lui; Yu Wei Chen; Shang Wei Chou; Pi Tai Chou; Kin Lam YUNG; S. C. Edman Tsang

doi:10.1088/1361-6528/aa96eb

Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents

Yung Kang Peng, Cathy N.P. Lui, Yu Wei Chen, Shang Wei Chou, Pi Tai Chou, Kin Lam YUNG^*, S. C. Edman Tsang^*

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localisation (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T ₂-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent for neural stem cells (NSCs) imaging and magnetic manipulation in live rodents. As a result, using this engineered nanoparticle and associated technologies, identification, stimulation and transportation of labelled potentially multipotent NSCs from a specific location of a live brain to another by magnetic means for self-healing therapy can therefore be made possible.

Original language	English
Article number	015102
Journal	Nanotechnology
Volume	29
Issue number	1
Early online date	4 Dec 2017
DOIs	https://doi.org/10.1088/1361-6528/aa96eb
Publication status	Published - 5 Jan 2018

Scopus Subject Areas

Bioengineering
Chemistry(all)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

User-Defined Keywords

cell harvesting
Magnetic field engineering
neural stem cells
safe magnetic manipulation
T1-T2 dual MR imaging

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10.1088/1361-6528/aa96eb

Cite this

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title = "Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents",

abstract = "Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localisation (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T 2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent for neural stem cells (NSCs) imaging and magnetic manipulation in live rodents. As a result, using this engineered nanoparticle and associated technologies, identification, stimulation and transportation of labelled potentially multipotent NSCs from a specific location of a live brain to another by magnetic means for self-healing therapy can therefore be made possible.",

keywords = "cell harvesting, Magnetic field engineering, neural stem cells, safe magnetic manipulation, T1-T2 dual MR imaging",

author = "Peng, {Yung Kang} and Lui, {Cathy N.P.} and Chen, {Yu Wei} and Chou, {Shang Wei} and Chou, {Pi Tai} and YUNG, {Kin Lam} and {Edman Tsang}, {S. C.}",

note = "Funding Information: We thank the EPSRC of UK for funding of this project. YKP acknowledges the University of Oxford Clarendon Fund Scholarship for his DPhil study. YKP and SCET are grateful to HKPU for the academic visiting scheme to partially support this work. CNPL and KKLY are grateful to NFSC and HKBU for funding support. We also thank KE and YA from Chinese University of HK for the support in Prussian blue staining experiment. We are indebted to the support from Taiwan Mouse Clinic which is currently funded through the National Research Program for Biopharmaceuticals (NRPB) at the Ministry of Science and Technology of Taiwan, particularly for the MRI mouse experiments presented in this paper.",

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AU - Peng, Yung Kang

AU - Lui, Cathy N.P.

AU - Chen, Yu Wei

AU - Chou, Shang Wei

AU - Chou, Pi Tai

AU - YUNG, Kin Lam

AU - Edman Tsang, S. C.

N1 - Funding Information: We thank the EPSRC of UK for funding of this project. YKP acknowledges the University of Oxford Clarendon Fund Scholarship for his DPhil study. YKP and SCET are grateful to HKPU for the academic visiting scheme to partially support this work. CNPL and KKLY are grateful to NFSC and HKBU for funding support. We also thank KE and YA from Chinese University of HK for the support in Prussian blue staining experiment. We are indebted to the support from Taiwan Mouse Clinic which is currently funded through the National Research Program for Biopharmaceuticals (NRPB) at the Ministry of Science and Technology of Taiwan, particularly for the MRI mouse experiments presented in this paper.

PY - 2018/1/5

Y1 - 2018/1/5

N2 - Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localisation (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T 2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent for neural stem cells (NSCs) imaging and magnetic manipulation in live rodents. As a result, using this engineered nanoparticle and associated technologies, identification, stimulation and transportation of labelled potentially multipotent NSCs from a specific location of a live brain to another by magnetic means for self-healing therapy can therefore be made possible.

AB - Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localisation (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T 2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent for neural stem cells (NSCs) imaging and magnetic manipulation in live rodents. As a result, using this engineered nanoparticle and associated technologies, identification, stimulation and transportation of labelled potentially multipotent NSCs from a specific location of a live brain to another by magnetic means for self-healing therapy can therefore be made possible.

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Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents

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