TY - JOUR
T1 - Endothelial cell and T-cell crosstalk
T2 - Targeting metabolism as a therapeutic approach in chronic inflammation
AU - Certo, Michelangelo
AU - Elkafrawy, Hagar
AU - Pucino, Valentina
AU - Cucchi, Danilo
AU - Cheung, Kenneth C.P.
AU - Mauro, Claudio
N1 - Funding Information:
This work has been supported by the British Heart Foundation (Fellowship FS/12/38/29640), Fondazione Cariplo (2015-0552), and the University of Birmingham Professorial Research Fellowship to C.M. We would like to thank Jennifer Niven for critical reading of the manuscript. Figures were created with BioRender.com.
Publisher Copyright:
© 2020 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society
PY - 2021/5
Y1 - 2021/5
N2 - The role of metabolic reprogramming in the coordination of the immune response has gained increasing consideration in recent years. Indeed, it has become clear that changes in the metabolic status of immune cells can alter their functional properties. During inflammation, T cells need to generate sufficient energy and biomolecules to support growth, proliferation, and effector functions. Therefore, T cells need to rearrange their metabolism to meet these demands. A similar metabolic reprogramming has been described in endothelial cells, which have the ability to interact with and modulate the function of immune cells. In this overview, we will discuss recent insights in the complex crosstalk between endothelial cells and T cells as well as their metabolic reprogramming following activation. We highlight key components of this metabolic switch that can lead to the development of new therapeutics against chronic inflammatory disorders. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.
AB - The role of metabolic reprogramming in the coordination of the immune response has gained increasing consideration in recent years. Indeed, it has become clear that changes in the metabolic status of immune cells can alter their functional properties. During inflammation, T cells need to generate sufficient energy and biomolecules to support growth, proliferation, and effector functions. Therefore, T cells need to rearrange their metabolism to meet these demands. A similar metabolic reprogramming has been described in endothelial cells, which have the ability to interact with and modulate the function of immune cells. In this overview, we will discuss recent insights in the complex crosstalk between endothelial cells and T cells as well as their metabolic reprogramming following activation. We highlight key components of this metabolic switch that can lead to the development of new therapeutics against chronic inflammatory disorders. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.
UR - http://www.scopus.com/inward/record.url?scp=85081567376&partnerID=8YFLogxK
U2 - 10.1111/bph.15002
DO - 10.1111/bph.15002
M3 - Journal article
SN - 0007-1188
VL - 178
SP - 2041
EP - 2059
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 10
ER -