Endothelial cell and T-cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation

Michelangelo Certo, Hagar Elkafrawy, Valentina Pucino, Danilo Cucchi, Kenneth C.P. Cheung, Claudio Mauro*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

29 Citations (Scopus)


The role of metabolic reprogramming in the coordination of the immune response has gained increasing consideration in recent years. Indeed, it has become clear that changes in the metabolic status of immune cells can alter their functional properties. During inflammation, T cells need to generate sufficient energy and biomolecules to support growth, proliferation, and effector functions. Therefore, T cells need to rearrange their metabolism to meet these demands. A similar metabolic reprogramming has been described in endothelial cells, which have the ability to interact with and modulate the function of immune cells. In this overview, we will discuss recent insights in the complex crosstalk between endothelial cells and T cells as well as their metabolic reprogramming following activation. We highlight key components of this metabolic switch that can lead to the development of new therapeutics against chronic inflammatory disorders. 

LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.

Original languageEnglish
Pages (from-to)2041-2059
Number of pages19
JournalBritish Journal of Pharmacology
Issue number10
Early online date30 Jan 2020
Publication statusPublished - May 2021

Scopus Subject Areas

  • Pharmacology


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