Abstract
The present study determined the participation of different endogenous mediators in adaptive cytoprotection against gastric gland damage caused by ethanol in rabbits. Using the isolated gland preparation, pretreatment with 10−5M of either indomethacin, Nw-nitro-L-arginine methyl ester (L-NAME) or N-ethylmaleimide (NEM), but not of substance P antagonist, intensified the 10% (v/v) ethanol-induced gastric gland damage and lessened the degree of cytoprotection evoked by 2% (v/v) ethanol to a significant level. Co-administration with 10−4M of prostaglandin E2, L-arginine or glutathione to the respective groups completely reversed the above adverse effects. These results demonstrate the involvement of endogenous prostaglandins, nitric oxide and glutathione in gastric adaptive cytoprotection against the damaging action of ethanol in the rabbit gastric glands.
| Original language | English |
|---|---|
| Pages (from-to) | PL1-PL5 |
| Number of pages | 5 |
| Journal | Life Sciences |
| Volume | 56 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Nov 1994 |
Scopus Subject Areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
User-Defined Keywords
- adaptive cytoprotection
- gastric glands
- glutathione
- nitric oxide
- prostaglandins