Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

Sifeng Li; Zihao Wang; Haitao  Xiao; Zhaoxiang  Bian; Jun (Joelle)  Wang

doi:10.1039/D0CC03158E

Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

Sifeng Li, Zihao Wang, Haitao Xiao, Zhaoxiang Bian^*, Jun (Joelle) Wang^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

Original language	English
Pages (from-to)	7573-7576
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	55
DOIs	https://doi.org/10.1039/D0CC03158E
Publication status	Published - 14 Jul 2020

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/D0CC03158E

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title = "Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation",

abstract = "An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.",

author = "Sifeng Li and Zihao Wang and Haitao Xiao and Zhaoxiang Bian and Wang, {Jun (Joelle)}",

note = "Funding information: We gratefully acknowledge Shenzhen Overseas High-level Talents Innovation Plan of Technical Innovation Project (KQJSCX20180319114439973) for financial support. This communication is dedicated to Professor Albert. S. C. Chan on the occasion of his 70th birthday. Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2020 ",

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AU - Li, Sifeng

AU - Wang, Zihao

AU - Xiao, Haitao

AU - Bian, Zhaoxiang

AU - Wang, Jun (Joelle)

N1 - Funding information: We gratefully acknowledge Shenzhen Overseas High-level Talents Innovation Plan of Technical Innovation Project (KQJSCX20180319114439973) for financial support. This communication is dedicated to Professor Albert. S. C. Chan on the occasion of his 70th birthday. Publisher copyright: © The Royal Society of Chemistry 2020

PY - 2020/7/14

Y1 - 2020/7/14

N2 - An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

AB - An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

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EP - 7576

JO - Chemical Communications

JF - Chemical Communications

IS - 55

ER -

Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

Abstract

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