Enantioselective regulation of a metal complex in reversible binding to serum albumin: Dynamic helicity inversion signalled by circularly polarised luminescence

Craig P. Montgomery; Elizabeth J. New; David Parker; Robert D. Peacock

doi:10.1039/b810978h

Enantioselective regulation of a metal complex in reversible binding to serum albumin: Dynamic helicity inversion signalled by circularly polarised luminescence

Craig P. Montgomery
, Elizabeth J. New
, David Parker^*
, Robert D. Peacock

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

108 Citations (Scopus)

Abstract

The helicity of the (SSS)-Δ enantiomer of a terbium and europium(iii) complex is inverted on reversible binding to 'drug site II' of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.

Original language	English
Pages (from-to)	4261-4263
Number of pages	3
Journal	Chemical Communications
Issue number	36
Early online date	10 Sept 2008
DOIs	https://doi.org/10.1039/b810978h
Publication status	Published - 28 Sept 2008

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title = "Enantioselective regulation of a metal complex in reversible binding to serum albumin: Dynamic helicity inversion signalled by circularly polarised luminescence",

abstract = "The helicity of the (SSS)-Δ enantiomer of a terbium and europium(iii) complex is inverted on reversible binding to 'drug site II' of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.",

author = "Montgomery, \{Craig P.\} and New, \{Elizabeth J.\} and David Parker and Peacock, \{Robert D.\}",

note = "We thank EPSRC, CISbio (CPM), the Association of Commonwealth Universities (EJN) and the Royal Society for support; this communication is dedicated to Dr John M. Brown (Oxford University), a master in understanding chiral phenomena. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2008 ",

year = "2008",

month = sep,

day = "28",

doi = "10.1039/b810978h",

language = "English",

pages = "4261--4263",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Enantioselective regulation of a metal complex in reversible binding to serum albumin

T2 - Dynamic helicity inversion signalled by circularly polarised luminescence

AU - Montgomery, Craig P.

AU - New, Elizabeth J.

AU - Parker, David

AU - Peacock, Robert D.

N1 - We thank EPSRC, CISbio (CPM), the Association of Commonwealth Universities (EJN) and the Royal Society for support; this communication is dedicated to Dr John M. Brown (Oxford University), a master in understanding chiral phenomena. Publisher Copyright: © The Royal Society of Chemistry 2008

PY - 2008/9/28

Y1 - 2008/9/28

N2 - The helicity of the (SSS)-Δ enantiomer of a terbium and europium(iii) complex is inverted on reversible binding to 'drug site II' of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.

AB - The helicity of the (SSS)-Δ enantiomer of a terbium and europium(iii) complex is inverted on reversible binding to 'drug site II' of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.

UR - https://www.scopus.com/pages/publications/52649084229

UR - https://pubs.rsc.org/en/content/articlelanding/2008/cc/b810978h

U2 - 10.1039/b810978h

DO - 10.1039/b810978h

M3 - Journal article

C2 - 18802537

AN - SCOPUS:52649084229

SN - 1359-7345

SP - 4261

EP - 4263

JO - Chemical Communications

JF - Chemical Communications

IS - 36

ER -

Enantioselective regulation of a metal complex in reversible binding to serum albumin: Dynamic helicity inversion signalled by circularly polarised luminescence

Abstract

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