Enantioselective preparation of ferrocenyl amino phosphines and their cytotoxic activities

Stanton Hon Lung Kok, Wing Sze Lam, Albert Sun Chi Chan, Wai Yeung Wong, Roberto Gambari, Raymond Siu Ming Wong, Kenneth Ka Ho Lee, Johnny Cheuk On Tang*, Kim Hung Lam, Chung Hin Chui

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

5 Citations (Scopus)


In connection to our previously reported phosphine compounds as antitumor agents, this article describes the preparation of ferrocenyl amino-phosphine and their possible cytotoxic potential towards the human hepatocellular carcinoma cell line Hep3B. The preliminary results suggested that ferrocenyl amino-phosphines can be potential anti-tumour agents which might be considered as novel cancer chemotherapeutic agents. In particular, compounds 4b, 4d and 4f exhibit strong cytotoxicity with IC 50 < 5 μg ml -1. These compounds possess more promising cytotoxic activities than their precursor non-substituted ferrocene as well as the reference metallodrug cisplatin.

Original languageEnglish
Pages (from-to)881-885
Number of pages5
Issue number9
Publication statusPublished - Sept 2011

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry


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