Enantioselective Palladium-Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides

Zhiping Yang, Jun WANG

Research output: Contribution to journalArticlepeer-review

Abstract

A Pd-catalyzed hydrophosphinylation of alkyl and aryl-oxyallenes with phosphine oxides has been developed for the efficient and rapid construction of a family of chiral allylic phosphine oxides with a diverse range of functional groups. This methodology was further applied in the facile construction of chiral 2H-chromene and later stage functionalization of cholesterol.

Original languageEnglish
Pages (from-to)27288-27292
Number of pages5
JournalAngewandte Chemie. International Edition
Volume60
Issue number52
Early online date28 Sep 2021
DOIs
Publication statusPublished - 20 Dec 2021

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • allene
  • allylic compound
  • hydrophosphinylation
  • palladium
  • synthetic method

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