Abstract
A Pd-catalyzed hydrophosphinylation of alkyl and aryl-oxyallenes with phosphine oxides has been developed for the efficient and rapid construction of a family of chiral allylic phosphine oxides with a diverse range of functional groups. This methodology was further applied in the facile construction of chiral 2H-chromene and later stage functionalization of cholesterol.
| Original language | English |
|---|---|
| Pages (from-to) | 27288-27292 |
| Number of pages | 5 |
| Journal | Angewandte Chemie. International Edition |
| Volume | 60 |
| Issue number | 52 |
| Early online date | 28 Sept 2021 |
| DOIs | |
| Publication status | Published - 20 Dec 2021 |
Scopus Subject Areas
- Catalysis
- Chemistry(all)
User-Defined Keywords
- allene
- allylic compound
- hydrophosphinylation
- palladium
- synthetic method