Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines

Qingjing Yang; Jian Zhou; Jun (Joelle) Wang

doi:10.1039/D2SC06950D

Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines

Qingjing Yang, Jian Zhou, Jun (Joelle) Wang^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

31 Citations (Scopus)

Abstract

An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides a direct and atom-efficient approach to prepare a variety of chiral phosphines with an isoquinoline unit in good yields and high enantioselectivities. In addition, these chiral phosphine products are useful bidentate P,N-ligands which showed potential application in asymmetric catalysis.

Original language	English
Pages (from-to)	4413-4417
Number of pages	5
Journal	Chemical Science
Volume	14
Issue number	16
Early online date	21 Mar 2023
DOIs	https://doi.org/10.1039/D2SC06950D
Publication status	Published - 28 Apr 2023

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10.1039/D2SC06950D

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title = "Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines",

abstract = "An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides a direct and atom-efficient approach to prepare a variety of chiral phosphines with an isoquinoline unit in good yields and high enantioselectivities. In addition, these chiral phosphine products are useful bidentate P,N-ligands which showed potential application in asymmetric catalysis.",

author = "Qingjing Yang and Jian Zhou and Wang, {Jun (Joelle)}",

note = "Funding Information: We gratefully thank the Research Grants Council of Hong Kong (GRF 12301821) and National Natural Science Foundation of China (NSFC 21971102) for financial support. Dr Xiaoyong Chang from SUSTech is gratefully acknowledged for X-ray crystallographic analysis. Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

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T1 - Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines

AU - Yang, Qingjing

AU - Zhou, Jian

AU - Wang, Jun (Joelle)

N1 - Funding Information: We gratefully thank the Research Grants Council of Hong Kong (GRF 12301821) and National Natural Science Foundation of China (NSFC 21971102) for financial support. Dr Xiaoyong Chang from SUSTech is gratefully acknowledged for X-ray crystallographic analysis. Publisher Copyright: © 2023 The Royal Society of Chemistry.

PY - 2023/4/28

Y1 - 2023/4/28

N2 - An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides a direct and atom-efficient approach to prepare a variety of chiral phosphines with an isoquinoline unit in good yields and high enantioselectivities. In addition, these chiral phosphine products are useful bidentate P,N-ligands which showed potential application in asymmetric catalysis.

AB - An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides a direct and atom-efficient approach to prepare a variety of chiral phosphines with an isoquinoline unit in good yields and high enantioselectivities. In addition, these chiral phosphine products are useful bidentate P,N-ligands which showed potential application in asymmetric catalysis.

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DO - 10.1039/D2SC06950D

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VL - 14

SP - 4413

EP - 4417

JO - Chemical Science

JF - Chemical Science

IS - 16

ER -

Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines

Abstract

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