Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines

Qingjing Yang, Jian Zhou, Jun (Joelle) Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

8 Citations (Scopus)


An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides a direct and atom-efficient approach to prepare a variety of chiral phosphines with an isoquinoline unit in good yields and high enantioselectivities. In addition, these chiral phosphine products are useful bidentate P,N-ligands which showed potential application in asymmetric catalysis.
Original languageEnglish
Pages (from-to)4413-4417
Number of pages5
JournalChemical Science
Issue number16
Early online date21 Mar 2023
Publication statusPublished - 28 Apr 2023

Scopus Subject Areas

  • Chemistry(all)


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