Enantioselective cellular localisation of europium(iii) coordination complexes

Andrew T. Frawley; Holly V. Linford; Matthieu Starck; Robert Pal; David Parker

doi:10.1039/c7sc04422d

Enantioselective cellular localisation of europium(iii) coordination complexes

Andrew T. Frawley
, Holly V. Linford
, Matthieu Starck
, Robert Pal
, David Parker^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

43 Citations (Scopus)

Abstract

The selective mitochondrial localisation of the Λ enantiomer of three different emissive europium(iii) complexes in NIH 3T3 and MCF7 cells contrasts with the behaviour of the Δ enantiomer, for which a predominant lysosomal localisation was observed by confocal microscopy. In each case, cell uptake occurs via macropinocytosis.

Original language	English
Pages (from-to)	1042-1049
Number of pages	8
Journal	Chemical Science
Volume	9
Issue number	4
Early online date	6 Dec 2017
DOIs	https://doi.org/10.1039/c7sc04422d
Publication status	Published - 28 Jan 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1039/c7sc04422dLicence: CC BY

Cite this

@article{d45da14b205d4b4391ed8a1793f5dc77,

title = "Enantioselective cellular localisation of europium(iii) coordination complexes",

abstract = "The selective mitochondrial localisation of the Λ enantiomer of three different emissive europium(iii) complexes in NIH 3T3 and MCF7 cells contrasts with the behaviour of the Δ enantiomer, for which a predominant lysosomal localisation was observed by confocal microscopy. In each case, cell uptake occurs via macropinocytosis.",

author = "Frawley, \{Andrew T.\} and Linford, \{Holly V.\} and Matthieu Starck and Robert Pal and David Parker",

note = "We thank EPSRC and The Royal Society for support. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

month = jan,

day = "28",

doi = "10.1039/c7sc04422d",

language = "English",

volume = "9",

pages = "1042--1049",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Enantioselective cellular localisation of europium(iii) coordination complexes

AU - Frawley, Andrew T.

AU - Linford, Holly V.

AU - Starck, Matthieu

AU - Pal, Robert

AU - Parker, David

PY - 2018/1/28

Y1 - 2018/1/28

N2 - The selective mitochondrial localisation of the Λ enantiomer of three different emissive europium(iii) complexes in NIH 3T3 and MCF7 cells contrasts with the behaviour of the Δ enantiomer, for which a predominant lysosomal localisation was observed by confocal microscopy. In each case, cell uptake occurs via macropinocytosis.

AB - The selective mitochondrial localisation of the Λ enantiomer of three different emissive europium(iii) complexes in NIH 3T3 and MCF7 cells contrasts with the behaviour of the Δ enantiomer, for which a predominant lysosomal localisation was observed by confocal microscopy. In each case, cell uptake occurs via macropinocytosis.

UR - https://www.scopus.com/pages/publications/85041238577

UR - https://pubs.rsc.org/en/content/articlelanding/2018/sc/c7sc04422d

U2 - 10.1039/c7sc04422d

DO - 10.1039/c7sc04422d

M3 - Journal article

AN - SCOPUS:85041238577

SN - 2041-6520

VL - 9

SP - 1042

EP - 1049

JO - Chemical Science

JF - Chemical Science

IS - 4

ER -

Enantioselective cellular localisation of europium(iii) coordination complexes

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this