Enantioselective binding of a lanthanide(iii) complex to human serum albumin studied by 1H STD NMR techniques

David M. Dias; João M.C. Teixeira; Ilya Kuprov; Elizabeth J. New; David Parker; Carlos F.G.C. Geraldes

doi:10.1039/c1ob05524k

Enantioselective binding of a lanthanide(iii) complex to human serum albumin studied by ¹H STD NMR techniques

David M. Dias
, João M.C. Teixeira
, Ilya Kuprov
, Elizabeth J. New
, David Parker
, Carlos F.G.C. Geraldes^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

15 Citations (Scopus)

Abstract

The enantioselective binding of the (SSS)-Δ isomer of an yttrium(iii) tetraazatriphenylene complex to 'drug-site II' of human serum albumin (HSA) was detected by the intensity differences of its STD ¹H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D docking simulations.

Original language	English
Pages (from-to)	5047-5050
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	14
Early online date	18 May 2011
DOIs	https://doi.org/10.1039/c1ob05524k
Publication status	Published - 21 Jul 2011

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10.1039/c1ob05524k

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title = "Enantioselective binding of a lanthanide(iii) complex to human serum albumin studied by 1H STD NMR techniques",

abstract = "The enantioselective binding of the (SSS)-Δ isomer of an yttrium(iii) tetraazatriphenylene complex to 'drug-site II' of human serum albumin (HSA) was detected by the intensity differences of its STD 1H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D docking simulations.",

author = "Dias, \{David M.\} and Teixeira, \{Jo{\~a}o M.C.\} and Ilya Kuprov and New, \{Elizabeth J.\} and David Parker and Geraldes, \{Carlos F.G.C.\}",

note = "We thank the Association of Commonwealth Universities (EJN), the Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia (FCT), Portugal (project PTDC/QUI/70063/2006) FEDER and ESF-COST D38 for support. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2011",

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doi = "10.1039/c1ob05524k",

language = "English",

volume = "9",

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journal = "Organic and Biomolecular Chemistry",

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T1 - Enantioselective binding of a lanthanide(iii) complex to human serum albumin studied by 1H STD NMR techniques

AU - Dias, David M.

AU - Teixeira, João M.C.

AU - Kuprov, Ilya

AU - New, Elizabeth J.

AU - Parker, David

AU - Geraldes, Carlos F.G.C.

N1 - We thank the Association of Commonwealth Universities (EJN), the Fundação para a Ciência e Tecnologia (FCT), Portugal (project PTDC/QUI/70063/2006) FEDER and ESF-COST D38 for support. Publisher Copyright: © The Royal Society of Chemistry 2011

PY - 2011/7/21

Y1 - 2011/7/21

N2 - The enantioselective binding of the (SSS)-Δ isomer of an yttrium(iii) tetraazatriphenylene complex to 'drug-site II' of human serum albumin (HSA) was detected by the intensity differences of its STD 1H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D docking simulations.

AB - The enantioselective binding of the (SSS)-Δ isomer of an yttrium(iii) tetraazatriphenylene complex to 'drug-site II' of human serum albumin (HSA) was detected by the intensity differences of its STD 1H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D docking simulations.

UR - https://doi.org/10.1039/C1OB90070F

UR - https://www.scopus.com/pages/publications/79959797736

UR - https://pubs.rsc.org/en/content/articlelanding/2011/ob/c1ob05524k

U2 - 10.1039/c1ob05524k

DO - 10.1039/c1ob05524k

M3 - Journal article

AN - SCOPUS:79959797736

SN - 1477-0520

VL - 9

SP - 5047

EP - 5050

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 14

ER -

Enantioselective binding of a lanthanide(iii) complex to human serum albumin studied by ¹H STD NMR techniques

Abstract

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