TY - JOUR
T1 - Emerging Roles of microRNAs in Plant Heavy Metal Tolerance and Homeostasis
AU - Ding, Yanfei
AU - Ding, Lihong
AU - Xia, Yiji
AU - Wang, Feijuan
AU - Zhu, Cheng
N1 - Funding Information:
This work is supported by grants from the National Natural Science Foundation of China (31771698) and the Natural Science Foundation of Zhejiang Province (LR17C130001, LY19C020001, and LQ18C020001).
Publisher copyright:
© 2020 American Chemical Society
PY - 2020/2/19
Y1 - 2020/2/19
N2 - Heavy metal stress is a major growth- and yield-limiting factor for plants. Heavy metals include essential metals (copper, iron, zinc, and manganese) and non-essential metals (cadmium, mercury, aluminum, arsenic, and lead). Plants use complex mechanisms of gene regulation under heavy metal stress. MicroRNAs are 21-nucleotide non-coding small RNAs as important modulators of gene expression post-transcriptionally. Recently, high-throughput sequencing has led to the identification of an increasing number of heavy-metal-responsive microRNAs in plants. Metal-regulated microRNAs and their target genes are part of a complex regulatory network that controls various biological processes, including heavy metal uptake and transport, protein folding and assembly, metal chelation, scavenging of reactive oxygen species, hormone signaling, and microRNA biogenesis. In this review, we summarize the recent molecular studies that identify heavy-metal-regulated microRNAs and their roles in the regulation of target genes as part of the microRNA-associated regulatory network in response to heavy metal stress in plants.
AB - Heavy metal stress is a major growth- and yield-limiting factor for plants. Heavy metals include essential metals (copper, iron, zinc, and manganese) and non-essential metals (cadmium, mercury, aluminum, arsenic, and lead). Plants use complex mechanisms of gene regulation under heavy metal stress. MicroRNAs are 21-nucleotide non-coding small RNAs as important modulators of gene expression post-transcriptionally. Recently, high-throughput sequencing has led to the identification of an increasing number of heavy-metal-responsive microRNAs in plants. Metal-regulated microRNAs and their target genes are part of a complex regulatory network that controls various biological processes, including heavy metal uptake and transport, protein folding and assembly, metal chelation, scavenging of reactive oxygen species, hormone signaling, and microRNA biogenesis. In this review, we summarize the recent molecular studies that identify heavy-metal-regulated microRNAs and their roles in the regulation of target genes as part of the microRNA-associated regulatory network in response to heavy metal stress in plants.
KW - gene regulation
KW - heavy metal
KW - microRNA
KW - response
KW - target
KW - tolerance
UR - http://www.scopus.com/inward/record.url?scp=85080151333&partnerID=8YFLogxK
U2 - 10.1021/acs.jafc.9b07468
DO - 10.1021/acs.jafc.9b07468
M3 - Journal article
C2 - 32003983
AN - SCOPUS:85080151333
SN - 0021-8561
VL - 68
SP - 1958
EP - 1965
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 7
ER -