TY - JOUR
T1 - Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout
T2 - Insights and therapeutic strategies
AU - Singh, Abhay Kumar
AU - Kumar Durairajan, Siva Sundara
AU - Durairajan, Siva Sundara Kumar
AU - Iyaswamy, Ashok
AU - Williams, Leonard L.
N1 - Publisher Copyright:
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
PY - 2024/10/28
Y1 - 2024/10/28
N2 - Hyperuricemia (HUA) is a condition associated with a high concentration of uric acid (UA) in the bloodstream and can cause gout and chronic kidney disease. The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people. This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder. Some studies have suggested that changes in the composition, diversity, and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis. Therefore, we discussed how the gut microbiota contributes to HUA through purine metabolism, UA excretion, and intestinal inflammatory responses. We examined specific changes in the composition of the gut microbiota associated with gout and HUA, highlighting key bacterial taxa and the metabolic pathways involved. Additionally, we discussed the effect of conventional gout treatments on the gut microbiota composition, along with emerging therapeutic approaches that target the gut microbiome, such as the use of probiotics and prebiotics. We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.
AB - Hyperuricemia (HUA) is a condition associated with a high concentration of uric acid (UA) in the bloodstream and can cause gout and chronic kidney disease. The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people. This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder. Some studies have suggested that changes in the composition, diversity, and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis. Therefore, we discussed how the gut microbiota contributes to HUA through purine metabolism, UA excretion, and intestinal inflammatory responses. We examined specific changes in the composition of the gut microbiota associated with gout and HUA, highlighting key bacterial taxa and the metabolic pathways involved. Additionally, we discussed the effect of conventional gout treatments on the gut microbiota composition, along with emerging therapeutic approaches that target the gut microbiome, such as the use of probiotics and prebiotics. We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.
KW - Dysbiosis
KW - Fecal microbiota transplantation
KW - Gout
KW - Gut microbiota
KW - Hyperuricemia
KW - Inflammation
KW - Intestinal barrier
KW - Prebiotics
KW - Probiotics
UR - http://www.scopus.com/inward/record.url?scp=85207342867&partnerID=8YFLogxK
U2 - 10.3748/wjg.v30.i40.4404
DO - 10.3748/wjg.v30.i40.4404
M3 - Journal article
C2 - 39494101
AN - SCOPUS:85207342867
SN - 1007-9327
VL - 30
SP - 4404
EP - 4410
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 40
ER -