Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout: Insights and therapeutic strategies

Abhay Kumar Singh, Siva Sundara Kumar Durairajan*, Siva Sundara Kumar Durairajan, Ashok Iyaswamy, Leonard L. Williams

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

1 Citation (Scopus)

Abstract

Hyperuricemia (HUA) is a condition associated with a high concentration of uric acid (UA) in the bloodstream and can cause gout and chronic kidney disease. The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people. This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder. Some studies have suggested that changes in the composition, diversity, and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis. Therefore, we discussed how the gut microbiota contributes to HUA through purine metabolism, UA excretion, and intestinal inflammatory responses. We examined specific changes in the composition of the gut microbiota associated with gout and HUA, highlighting key bacterial taxa and the metabolic pathways involved. Additionally, we discussed the effect of conventional gout treatments on the gut microbiota composition, along with emerging therapeutic approaches that target the gut microbiome, such as the use of probiotics and prebiotics. We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.

Original languageEnglish
Pages (from-to)4404-4410
Number of pages7
JournalWorld Journal of Gastroenterology
Volume30
Issue number40
DOIs
Publication statusPublished - 28 Oct 2024

Scopus Subject Areas

  • Gastroenterology

User-Defined Keywords

  • Dysbiosis
  • Fecal microbiota transplantation
  • Gout
  • Gut microbiota
  • Hyperuricemia
  • Inflammation
  • Intestinal barrier
  • Prebiotics
  • Probiotics

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