姜黄素治疗口腔黏膜下纤维性变有效性的Meta分析

Translated title of the contribution: Efficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis

郭锦材, 谢辉, 吴昊, 童铁军

Research output: Contribution to journalArticlepeer-review

Abstract

目的: 系统性地评价姜黄素治疗口腔黏膜下纤维性变的有效性。方法: 检索Web of Science、PubMed、EBSCO、The Cochrane Library、中国知网、万方和维普7个数据库,检索时限为从建库到2019年6月30日,搜集姜黄素治疗口腔黏膜下纤维性变的随机对照试验,筛选文献,提取数据,用RevMan 5.3软件进行Meta分析。结果: 纳入6个随机对照试验,共350名患者。Meta分析结果显示,姜黄素改善口腔黏膜下纤维性变的最大张口度和烧灼感症状疗效优于安慰剂。改善张口度方面,治疗1个月后,姜黄素疗效不如番茄红素等控制组;但治疗2个月、3个月和6个月后姜黄素组和控制组疗效相似,差异无统计学意义。烧灼感改善方面,治疗3个月后,姜黄素的疗效比控制组更好,且差异有统计学意义;治疗1个月、2个月和6个月后,姜黄素组和控制组的疗效差异无统计学意义。结论: 当前证据显示,姜黄素可以有效地改善口腔黏膜下纤维性变患者的最大张口度和烧灼感等症状。由于纳入研究数量有限和质量不高,上述结论尚需更多高质量研究予以验证。

Objective: This study was performed to review the efficacy of curcumin in the treatment of oral submucous fibrosis systematically.

Methods: We searched seven databases, including Web of Science, PubMed, EBSCO, The Cochrane Library, CNKI, WanFang Data, and VIP, to obtain randomized controlled trials related to the treatment of oral submucous fibrosis by curcumin. Each database was searched from inception to 30 June 2019. RevMan 5.3 software was used for the meta-analysis.

Results: Six randomized controlled trials involving 350 patients were included in this study. Meta-analysis showed that curcumin can increase the maximal mouth opening and improve burning sensation compared with placebo treatment. Curcumin was not as effective as the controls in achieving maximal mouth opening after 1 month of treatment. However, no statistically significant difference was observed between the treatments from 2 months to 6 months. Curcumin significantly improved burning sensation compared with the controls after 3 months of treatment. No statistically significant diffe-rence in burning sensation was observed between the curcumin and control groups after 1, 2, and 6 months of treatment.

Conclusion: The current evidence shows that curcumin is an effective treatment for improving maximal mouth opening and burning sensation in patients with oral submucous fibrosis. Given the limited number and low quality of the included studies, however, more high-quality studies are needed to verify these findings.

Translated title of the contributionEfficacy of curcumin in the treatment of oral submucous fibrosis: a Meta-analysis
Original languageChinese (Simplified)
Pages (from-to)195-202
Number of pages8
Journal华西口腔医学杂志
Volume39
Issue number2
DOIs
Publication statusPublished - 1 Apr 2021

Scopus Subject Areas

  • Medicine(all)

User-Defined Keywords

  • 口腔黏膜下纤维性变
  • 姜黄素
  • Meta 分析
  • 循证医学
  • curcumin
  • evidence-based medicine
  • Meta-analysis
  • oral submucous fibrosis

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