Effects of the modified Huanglian Jiedu decoction on the disease resistance in grey mullet (Mugil cephalus) to Lactococcus garvieae

W. M. Choi, C. L. Lam, W. Y. Mo, Z. Cheng, Nai Ki MAK, Zhaoxiang BIAN, Ming Hung WONG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Lactococcosis is prevalent on grey mullet (Mugil cephalus) in Hong Kong aquaculture resulting in serious economic loss. A compound formulation of Traditional Chinese Medicines (TCM) (modified Huanglian Jiedu decoction (HLJDD)) comprising Rhizoma coptidis, Radix scutellaria, Cortex phellodendri, Fructus gardeniae, Fructus forsythiae and Flos lonicerae japonicae (in a ratio of 3:2:2:3:3:5) were applied as feed supplements to deal with the disease. The Nitroblue tetrazolium activity in blood, bactericidal activity and total immunoglobulin in plasma were significantly enhanced after feeding 1% of this TCM for 28 days. The disease resistances to Lactococcus garvieae in 1% and 2% TCM feeding groups were significantly enhanced. In the in vitro study, the modified HLJDD also activated the plasma bactericidal activities (p< 0.01). Based on this study, 1% modified HLJDD feeding for 28 days may be an optimal dose to prevent L. garvieae infection and could be used in aquaculture industries.

Original languageEnglish
Pages (from-to)816-823
Number of pages8
JournalMarine Pollution Bulletin
Volume85
Issue number2
DOIs
Publication statusPublished - 30 Aug 2014

Scopus Subject Areas

  • Oceanography
  • Aquatic Science
  • Pollution

User-Defined Keywords

  • Aquaculture
  • Bactericidal activity
  • Grey mullet
  • Lactococcus garvieae
  • Traditional Chinese Medicine

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