Effects of pollutant toxicity on the eyes of aquatic life monitored by visual dysfunction in zebrafish: a review

Xiao Fan Chen, Zhi Cheng Lin, Zenghua Qi, Zongwei Cai, Zhi Feng Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

6 Citations (Scopus)

Abstract

The eyes of aquatic organisms may be damaged by exposure to pollutants. Zebrafish is a common laboratory model to study ocular toxicity, combining both fish and vertebrate characteristics. The toxic effects on zebrafish eyes caused by pollutants include morphological changes and damage to the retina at the molecular, cellular, and tissue levels; and abnormalities in the visual phototransduction and electrical signal transmission processes. Such damage induces functional disorders of vision-related behaviors. The underlying mechanisms include thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. Here, we review the ocular toxicity phenotypes and related signaling pathways induced by contaminants. We present detection methods and emerging tools for studying ocular toxicity. We also propose a model to predict the potential ocular toxicity of contaminants.

Original languageEnglish
Pages (from-to)1177-1201
Number of pages25
JournalEnvironmental Chemistry Letters
Volume21
Issue number2
Early online date14 Oct 2022
DOIs
Publication statusPublished - Apr 2023

Scopus Subject Areas

  • Environmental Chemistry

User-Defined Keywords

  • Adverse outcome pathway
  • Environmental pollutant
  • Ocular toxicity
  • Research technique
  • Signaling pathway
  • Zebrafish

Fingerprint

Dive into the research topics of 'Effects of pollutant toxicity on the eyes of aquatic life monitored by visual dysfunction in zebrafish: a review'. Together they form a unique fingerprint.

Cite this