Effects of neonatal monosodium-L-glutamate treatment on rat alveolar macrophages

W. K. Liu*, C. C. Wong, Nai Ki MAK

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Treatment of neonatal rats with repeated doses of monosodium-L-glutamate resulted in changes of morphology and function of alveolar macrophages recovered from adult female rats. Numerous cellular lipid vacuoles and lamellar structures were observed in these alveolar macrophages under transmission electron microscopy. There was approximately 50% increase of cellular total lipid content measured by Oil-Red-O staining and colorimetric method. The yeast phagocytosis and intracellular killing ability, as well as the inhibitory effect on the growth of tumor cells were reduced in alveolar macrophages from neonatal MSG-treated rats.

Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalChemico-Biological Interactions
Volume69
Issue number2-3
DOIs
Publication statusPublished - 1989

Scopus Subject Areas

  • Toxicology

User-Defined Keywords

  • Alveolar macrophages
  • Lipid
  • Monosodium-L-glutamate

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