Effects of euxanthone on neuronal differentiation

Nai Ki MAK, Li Wen-Kui, Meng Zhang, Ricky N S WONG, Lai-Shan Tai, Kin Lam YUNG, Hi Wun Leung

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The growth inhibitory and differentiation inducing effects of euxanthone (1,7-dihydroxyxanthone) from the medicinal plant Polygala caudata on the neuroblastoma (Neural 2A, subclone BU-1) were investigated. At the concentration range of 0 - 100μM, euxanthone inhibits the growth of BU-1 cells in a dose dependent manner. The 50% growth inhibitory concentration (IC50) was 41μM. Significant induction of morphological differentiation and neurite growth was observed at the concentration of 100μM. Frequency of proliferative neuroblastoma cells was determined after induction of differentiation. The frequency of proliferating BU-1 cells was markedly reduced from 1/1.1 to <1/99. Confocal microscopy also confirmed that the morphological differentiation of BU-1 was associated with the expression of neurite specific marker MAP-2 protein in neurites. These data suggest that euxanthone may be one of the neuropharmacological active compounds in the medicinal plant Polygala caudata.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalLife Sciences
Volume66
Issue number4
DOIs
Publication statusPublished - 14 Dec 1999

Scopus Subject Areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

User-Defined Keywords

  • Euxanthone
  • Laser scanning confocal microscopy
  • Limiting dilution analysis
  • Neurite growth
  • Neuroblastoma

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