Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause

Stephen CW Sze, Ho-Pan Cheung, Tzi-Bun Ng, Zhang-Jing Zhang, Kam-Lok Wong, Hei-Kiu Wong, Yong-Mei Hu, Christine MN Yow, Yao Tong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background
The prevalence and risk of cardiovascular disease increase after menopause in correlation with the progression of abnormality in the serum lipid profile and the deprivation of estrogen. Erxian decoction (EXD), a Chinese medicinal formulation for treating menopausal syndrome, stimulates ovarian estrogen biosynthesis. This study investigates whether EXD improves the serum lipid profile in a menopausal rat model.

Methods
Twenty-month-old female Sprague Dawley rats were treated with EXD and its constituent fractions. Premarin was administered for comparison. After eight weeks of treatment, rats were sacrificed and the serum levels of total cholesterol, triglyceride, high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol were determined. The hepatic protein levels of 3-hydroxy-3-methyl-glutaryl-CoA reductase and low-density-lipoprotein receptor were assessed with Western blot.

Results
The serum levels of total cholesterol and low-density-lipoprotein cholesterol were significantly lower in the EXD-treated group than in the constituent fractions of EXD or premarin groups. However, the serum levels of triglyceride and high-density-lipoprotein cholesterol were not significantly different from the control groups. Results from Western blot suggest that EXD significantly down-regulated the protein level of 3-hydroxy-3-methyl-glutaryl-CoA reductase and up-regulated low-density-lipoprotein receptor. Conclusion EXD improves serum lipid profile in a menopausal rat model through the suppression of the serum levels of total cholesterol and low-density-lipoprotein cholesterol, possibly through the down-regulation of the 3-hydroxy-3-methyl-glutaryl-CoA and up-regulation of the low-density-lipoprotein receptor.
Original languageEnglish
Article number40
Number of pages10
JournalChinese Medicine
Volume6
DOIs
Publication statusPublished - 2 Nov 2011
Externally publishedYes

Scopus Subject Areas

  • Medicine(all)

User-Defined Keywords

  • Ferulic Acid
  • Berberine
  • Serum Lipid Level
  • Serum Lipid Profile
  • Serum Total Cholesterol Level

Fingerprint

Dive into the research topics of 'Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause'. Together they form a unique fingerprint.

Cite this