TY - JOUR
T1 - Effects of dietary and physical activity interventions on generic and cancer-specific health-related quality of life, anxiety, and depression in colorectal cancer survivors
T2 - a randomized controlled trial
AU - Ho, Mandy
AU - Ho, Judy W.C.
AU - Fong, Daniel Y.T.
AU - Lee, C. F.
AU - Macfarlane, Duncan J.
AU - Cerin, Ester
AU - Lee, Antoinette M.
AU - Leung, Sharron
AU - Chan, Wynnie Y.Y.
AU - Leung, Ivy P.F.
AU - Lam, Sharon H.S.
AU - Chu, Natural
AU - Taylor, Aliki J.
AU - Cheng, Kar Keung
N1 - Funding Information:
The study was funded by a grant from the World Cancer Research Fund International (WCRF 2012/595) & the Wereld Kanker Onderzoek Fords (WCRF NL). The funding body was not involved in the design of the study and collection, analysis, interpretation of data or in the writing the manuscript.
Funding Information:
The study was financially supported by the World Cancer Research Fund International (Reference number: 2012/595). We would also gratefully thank the surgical and oncological departments of Pamela Youde Nethersole Eastern Hospital, Princess Margaret Hospital, Queen Mary Hospital, and Yan Chai Hospital for participating in the trial, Dr. NF Shum for generating the randomization schedule, Ms. P Lau for randomizing patients according to the schedule, Ms. OS Yeung for delivering the interventions, Mr. D Lam for performing outcome assessment, Ms. WY Luk for clerical support, Ms. L Wong for assisting in statistical analysis, and all the patients who participated in the trial.
Funding Information:
The study was financially supported by the World Cancer Research Fund International (Reference number: 2012/595). We would also gratefully thank the surgical and oncological departments of Pamela Youde Nethersole Eastern Hospital, Princess Margaret Hospital, Queen Mary Hospital, and Yan Chai Hospital for participating in the trial, Dr. NF Shum for generating the randomization schedule, Ms. P Lau for randomizing patients according to the schedule, Ms. OS Yeung for delivering the interventions, Mr. D Lam for performing outcome assessment, Ms. WY Luk for clerical support, Ms. L Wong for assisting in statistical analysis, and all the patients who participated in the trial.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Purpose: To assess the effects of dietary and physical activity (PA) interventions on generic and cancer-specific quality of life (QoL), anxiety, and depression levels among adult Chinese colorectal cancer (CRC) survivors. Methods: Two-hundred twenty-three adult CRC survivors within 1 year of completion of primary cancer treatment were randomized to receive dietary, PA or combined intervention, or usual care for a 12 monthduration, under a 2 (diet vs usual care) × 2 (PA vs usual care) factorial design. Generic and cancer-specific QoL was assessed using a Chinese version 12-Item Short Form Health Survey (SF-12) and the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale, respectively. Anxiety and depression was assessed using the Hospital Anxiety and Depression Scale at baseline, 6, 12, 18, and 24 months. Linear mixed models were used for examining the intervention effects. Results: Participants receiving dietary intervention experienced a significant improvement in the generic measure of QoL (SF-6D utility scores, mean difference 0.042, 95%CI 0.03 to 0.081) at 12 months, the cancer-specific QoL scores (mean difference 3.09, 95%CI 0.13 to 6.04), and levels of depression (P = 0.015) at both 12 and 24 months follow-up. Participants receiving PA intervention only demonstrated a significant improvement in SF-6D utility index (mean difference 0.039, 95%CI 0.002 to 0.077) and physical functioning (mean difference 2.85, 95%CI 1.00 to 4.70) at 6 months. Conclusions: Dietary intervention improved the generic and cancer-specific QoL and depression in CRC survivors. Trial registration: The study was prospectively registered on 17 October 2012 at ClinicalTrials.gov (NCT01708824). Implications for Cancer Survivors: CRC survivors can benefit from dietary interventions in alleviating depression and improving overall health-related QoL.
AB - Purpose: To assess the effects of dietary and physical activity (PA) interventions on generic and cancer-specific quality of life (QoL), anxiety, and depression levels among adult Chinese colorectal cancer (CRC) survivors. Methods: Two-hundred twenty-three adult CRC survivors within 1 year of completion of primary cancer treatment were randomized to receive dietary, PA or combined intervention, or usual care for a 12 monthduration, under a 2 (diet vs usual care) × 2 (PA vs usual care) factorial design. Generic and cancer-specific QoL was assessed using a Chinese version 12-Item Short Form Health Survey (SF-12) and the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale, respectively. Anxiety and depression was assessed using the Hospital Anxiety and Depression Scale at baseline, 6, 12, 18, and 24 months. Linear mixed models were used for examining the intervention effects. Results: Participants receiving dietary intervention experienced a significant improvement in the generic measure of QoL (SF-6D utility scores, mean difference 0.042, 95%CI 0.03 to 0.081) at 12 months, the cancer-specific QoL scores (mean difference 3.09, 95%CI 0.13 to 6.04), and levels of depression (P = 0.015) at both 12 and 24 months follow-up. Participants receiving PA intervention only demonstrated a significant improvement in SF-6D utility index (mean difference 0.039, 95%CI 0.002 to 0.077) and physical functioning (mean difference 2.85, 95%CI 1.00 to 4.70) at 6 months. Conclusions: Dietary intervention improved the generic and cancer-specific QoL and depression in CRC survivors. Trial registration: The study was prospectively registered on 17 October 2012 at ClinicalTrials.gov (NCT01708824). Implications for Cancer Survivors: CRC survivors can benefit from dietary interventions in alleviating depression and improving overall health-related QoL.
KW - Anxiety
KW - Cancer survivorship
KW - Colorectal cancer
KW - Depression
KW - Dietary intervention
KW - Health-related quality of life
KW - Physical activity intervention
UR - http://www.scopus.com/inward/record.url?scp=85079784022&partnerID=8YFLogxK
U2 - 10.1007/s11764-020-00864-0
DO - 10.1007/s11764-020-00864-0
M3 - Journal article
C2 - 32072434
AN - SCOPUS:85079784022
SN - 1932-2259
VL - 14
SP - 424
EP - 433
JO - Journal of Cancer Survivorship
JF - Journal of Cancer Survivorship
IS - 4
ER -
