Effects of curcumin in treatment of experimental pulmonary fibrosis: A comparison with hydrocortisone

Min XU*, Bin Deng, Yeuk lung Chow, Zhongzhen ZHAO, Bin Hu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

To compare curcumin with hydrocortisone for treating bleomycin-induced pulmonary fibrosis (BLMPF), four groups of rats were injected with 1.5 mg/kg bleomycin intratracheally. Then the Group HC rats were treated with three injections of 2 mg/kg hydrocortisone i.p.; Group CH and CL rats, respectively, were orally given 500 or 250 mg/kg curcumin daily; and Group PC rats were given deionized water alone. After 28 days of treatment, lung samples were examined by H-E staining, Masson's staining and immunohistochemical analyses and pulmonary type I collagen (Col-I), inducible nitric oxide synthetase (iNOS) and transforming growth factor-β1 (TGF-β1) were determined by Western blotting and real-time RT PCR analyses. The results showed that (1) Group PC rats had histopathological characteristics of BLMPF with significant increase in their protein/mRNA expressions of Col-I (+114%/+173%), iNOS (+146%/+523%) and TGF-β1 (+476%/+527%) (P < 0.01); (2) in Group HC, CH and CL rats, protein/mRNA expressions of Col-I (-39%/-52%, -31%/-57%, -33%/-58%), iNOS (-31%/-51%, -31%/-79%, -31%/-47%) and TGF-β1 (-64%/-78%, -75%/-74%, -81%/-79%) were significantly lower than Group PC (P < 0.05); (3) except for levels of TGF-β1 protein, there was no significant difference among Group CH, CL and HC rats (P > 0.05). It suggests that curcumin may play a similar role as hydrocortisone in preventing BLMPF.

Original languageEnglish
Pages (from-to)292-299
Number of pages8
JournalJournal of Ethnopharmacology
Volume112
Issue number2
DOIs
Publication statusPublished - 13 Jun 2007

Scopus Subject Areas

  • Pharmacology
  • Drug Discovery

User-Defined Keywords

  • Bleomycin
  • Curcumin
  • Hydrocortisone
  • Pulmonary fibrosis

Fingerprint

Dive into the research topics of 'Effects of curcumin in treatment of experimental pulmonary fibrosis: A comparison with hydrocortisone'. Together they form a unique fingerprint.

Cite this