TY - JOUR
T1 - Effectiveness of exercise interventions in animal models of multiple sclerosis
AU - Parnow, Abdolhossein
AU - Hafedh, Muthanna
AU - Tsunoda, Ikuo
AU - Patel, Darpan I.
AU - Baker, Julien S.
AU - Saeidi, Ayoub
AU - Bagchi, Sovan
AU - Sengupta, Pallav
AU - Dutta, Sulagna
AU - Łuszczki, Edyta
AU - Stolarczyk, Artur
AU - Oleksy, Łukasz
AU - Al Kiyumi, Maisa Hamed
AU - Laher, Ismail
AU - Zouhal, Hassane
N1 - IT was supported by the Grants-in-Aid for Scientific Research KAKENHI (JP20K07455) from the Japan Society for the Promotion of Science (JSPS).
Publisher Copyright:
Copyright © 2023 Parnow, Hafedh, Tsunoda, Patel, Baker, Saeidi, Bagchi, Sengupta, Dutta, Łuszczki, Stolarczyk, Oleksy, Al Kiyumi, Laher and Zouhal.
PY - 2023/3/30
Y1 - 2023/3/30
N2 - Multiple sclerosis (MS) is associated with an impaired immune system that severely affects the spinal cord and brain, and which is marked by progressive inflammatory demyelination. Patients with MS may benefit from exercise training as a suggested course of treatment. The most commonly used animal models of studies on MS are experimental autoimmune/allergic encephalomyelitis (EAE) models. The present review intends to concisely discuss the interventions using EAE models to understand the effectiveness of exercise as treatment for MS patients and thereby provide clear perspective for future research and MS management. For the present literature review, relevant published articles on EAE animal models that reported the impacts of exercise on MS, were extracted from various databases. Existing literature support the concept that an exercise regimen can reduce the severity of some of the clinical manifestations of EAE, including neurological signs, motor function, pain, and cognitive deficits. Further results demonstrate the mechanisms of EAE suppression with information relating to the immune system, demyelination, regeneration, and exercise in EAE. The role for neurotrophic factors has also been investigated. Analyzing the existing reports, this literature review infers that EAE is a suitable animal model that can help researchers develop further understanding and treatments for MS. Besides, findings from previous animal studies supports the contention that exercise assists in ameliorating MS progression.
AB - Multiple sclerosis (MS) is associated with an impaired immune system that severely affects the spinal cord and brain, and which is marked by progressive inflammatory demyelination. Patients with MS may benefit from exercise training as a suggested course of treatment. The most commonly used animal models of studies on MS are experimental autoimmune/allergic encephalomyelitis (EAE) models. The present review intends to concisely discuss the interventions using EAE models to understand the effectiveness of exercise as treatment for MS patients and thereby provide clear perspective for future research and MS management. For the present literature review, relevant published articles on EAE animal models that reported the impacts of exercise on MS, were extracted from various databases. Existing literature support the concept that an exercise regimen can reduce the severity of some of the clinical manifestations of EAE, including neurological signs, motor function, pain, and cognitive deficits. Further results demonstrate the mechanisms of EAE suppression with information relating to the immune system, demyelination, regeneration, and exercise in EAE. The role for neurotrophic factors has also been investigated. Analyzing the existing reports, this literature review infers that EAE is a suitable animal model that can help researchers develop further understanding and treatments for MS. Besides, findings from previous animal studies supports the contention that exercise assists in ameliorating MS progression.
KW - EAE model
KW - exercise training
KW - motor function
KW - multiple sclerosis
KW - neurotrophin
UR - http://www.scopus.com/inward/record.url?scp=85153502056&partnerID=8YFLogxK
UR - https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1143766/full
U2 - 10.3389/fmed.2023.1143766
DO - 10.3389/fmed.2023.1143766
M3 - Review article
AN - SCOPUS:85153502056
SN - 2296-858X
VL - 10
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 1143766
ER -