With the increasing availability of moving-object tracking data, use of this data for route search and recommendation is increasingly important. To this end, we propose a novel parallel split-and-combine approach to enable route search by locations (RSL-Psc). Given a set of routes, a set of places to visit O, and a threshold ?, we retrieve the route composed of sub-routes that (i) has similarity to O no less than ? and (ii) contains the minimum number of sub-route combinations. The resulting functionality targets a broad range of applications, including route planning and recommendation, ridesharing, and location-based services in general. To enable efficient and effective RSL-Psc computation on massive route data, we develop novel search space pruning techniques and enable use of the parallel processing capabilities of modern processors. Specifically, we develop two parallel algorithms, Fully-Split Parallel Search (FSPS) and Group-Split Parallel Search (GSPS). We divide the route split-and-combine task into kM=0 S(|O|, k + 1) sub-tasks, where M is the maximum number of combinations and S(·) is the Stirling number of the second kind. In each sub-task, we use network expansion and exploit spatial similarity bounds for pruning. The algorithms split candidate routes into sub-routes and combine them to construct new routes. The sub-tasks are independent and are performed in parallel. Extensive experiments with real data offer insight into the performance of the algorithms, indicating that our RSL-Psc problem can generate high-quality results and that the two algorithms are capable of achieving high efficiency and scalability.