Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis

Ho Man Chan; Lehui Xiao; Kai Ming Yeung; See Lok Ho; Dan Zhao; Wing Hong Chan; Hung Wing Li

doi:10.1016/j.biomaterials.2012.03.024

Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis

Ho Man Chan
, Lehui Xiao
, Kai Ming Yeung
, See Lok Ho
, Dan Zhao
, Wing Hong Chan
, Hung Wing Li^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

65 Citations (Scopus)

Abstract

The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ _1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ _1-40 fibrillogenesis

Original language	English
Pages (from-to)	4443-4450
Number of pages	8
Journal	Biomaterials
Volume	33
Issue number	18
DOIs	https://doi.org/10.1016/j.biomaterials.2012.03.024
Publication status	Published - Jun 2012

User-Defined Keywords

Nanoparticle
Peptide
Self-assembly
Surface modification

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10.1016/j.biomaterials.2012.03.024

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title = "Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis",

abstract = "The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ 1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ 1-40 fibrillogenesis",

keywords = "Nanoparticle, Peptide, Self-assembly, Surface modification",

author = "Chan, \{Ho Man\} and Lehui Xiao and Yeung, \{Kai Ming\} and Ho, \{See Lok\} and Dan Zhao and Chan, \{Wing Hong\} and Li, \{Hung Wing\}",

note = "Funding Information: This work was fully supported by grants from the University Grant Council of Hong Kong Special Administrative Region, China ( HKBU 201208 ) and Faculty Research Grant from Hong Kong Baptist University ( FRG2/08-09/073 ) and ( FRG2/09-10/037 ). The FEI-Technai G2 TEM used in this work was supported by the Center for Surface Analysis and Research (CSAR) with funding from the Special Equipment Grant from the University Grant Committee of the Hong Kong Special Administrative Region, China ( SEG\_HKBU06 ). We thank Mr. Benson Leung (HKBU) and Mr. Roy Ho (HKUST) for TEM measurement. We also thank Dr. Kai-Chung Lau and Miss Queeny Lo of the City University of Hong Kong for zeta-potential measurement. ",

year = "2012",

month = jun,

doi = "10.1016/j.biomaterials.2012.03.024",

language = "English",

volume = "33",

pages = "4443--4450",

journal = "Biomaterials",

issn = "0142-9612",

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number = "18",

}

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T1 - Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis

AU - Chan, Ho Man

AU - Xiao, Lehui

AU - Yeung, Kai Ming

AU - Ho, See Lok

AU - Zhao, Dan

AU - Chan, Wing Hong

AU - Li, Hung Wing

N1 - Funding Information: This work was fully supported by grants from the University Grant Council of Hong Kong Special Administrative Region, China ( HKBU 201208 ) and Faculty Research Grant from Hong Kong Baptist University ( FRG2/08-09/073 ) and ( FRG2/09-10/037 ). The FEI-Technai G2 TEM used in this work was supported by the Center for Surface Analysis and Research (CSAR) with funding from the Special Equipment Grant from the University Grant Committee of the Hong Kong Special Administrative Region, China ( SEG_HKBU06 ). We thank Mr. Benson Leung (HKBU) and Mr. Roy Ho (HKUST) for TEM measurement. We also thank Dr. Kai-Chung Lau and Miss Queeny Lo of the City University of Hong Kong for zeta-potential measurement.

PY - 2012/6

Y1 - 2012/6

N2 - The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ 1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ 1-40 fibrillogenesis

AB - The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ 1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ 1-40 fibrillogenesis

KW - Nanoparticle

KW - Peptide

KW - Self-assembly

KW - Surface modification

UR - https://www.scopus.com/pages/publications/84862826842

U2 - 10.1016/j.biomaterials.2012.03.024

DO - 10.1016/j.biomaterials.2012.03.024

M3 - Journal article

C2 - 22459190

AN - SCOPUS:84862826842

SN - 0142-9612

VL - 33

SP - 4443

EP - 4450

JO - Biomaterials

JF - Biomaterials

IS - 18

ER -

Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis

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