Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis

Ho Man Chan, Lehui Xiao, Kai Ming Yeung, See Lok Ho, Dan Zhao, Wing Hong CHAN, Hung Wing LI*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ 1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ 1-40 fibrillogenesis

Original languageEnglish
Pages (from-to)4443-4450
Number of pages8
JournalBiomaterials
Volume33
Issue number18
DOIs
Publication statusPublished - Jun 2012

Scopus Subject Areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

User-Defined Keywords

  • Nanoparticle
  • Peptide
  • Self-assembly
  • Surface modification

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