@article{9d035c6aa89443b0afcffa711e6419ba,
title = "Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis",
abstract = "The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ 1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ 1-40 fibrillogenesis",
keywords = "Nanoparticle, Peptide, Self-assembly, Surface modification",
author = "Chan, {Ho Man} and Lehui Xiao and Yeung, {Kai Ming} and Ho, {See Lok} and Dan Zhao and CHAN, {Wing Hong} and LI, {Hung Wing}",
note = "Funding Information: This work was fully supported by grants from the University Grant Council of Hong Kong Special Administrative Region, China ( HKBU 201208 ) and Faculty Research Grant from Hong Kong Baptist University ( FRG2/08-09/073 ) and ( FRG2/09-10/037 ). The FEI-Technai G2 TEM used in this work was supported by the Center for Surface Analysis and Research (CSAR) with funding from the Special Equipment Grant from the University Grant Committee of the Hong Kong Special Administrative Region, China ( SEG_HKBU06 ). We thank Mr. Benson Leung (HKBU) and Mr. Roy Ho (HKUST) for TEM measurement. We also thank Dr. Kai-Chung Lau and Miss Queeny Lo of the City University of Hong Kong for zeta-potential measurement. ",
year = "2012",
month = jun,
doi = "10.1016/j.biomaterials.2012.03.024",
language = "English",
volume = "33",
pages = "4443--4450",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",
number = "18",
}