Effect of rhynchophylline on the expression of p-CREB and sc-Fos in triatum and hippocampal CA1 area of methamphetamine-induced conditioned place preference rats

Wei Liu, Qiu Xian Peng, Xiao Liang Lin, Chao Hua Luo, Ming Jin Jiang, Zhi Xian Mo*, Kin Lam YUNG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

To explore the effect of rhynchophylline (Rhy) on the expression of p-CREB and c-Fos in the striatum and hippocampal CA1 area of methamphetamine-induced conditioned place preference (CPP) rat, methamphetamine (2 mg/kg) was injected to rats and the conditioned place preference was observed in these rats treated with or without Rhy. An immunohistochemistry assay was used to determine the expression of p-CREB and c-Fos in the striatum and hippocampal CA1 area. Methamphetamine induced significant behavior alteration in CPP, while after pretreatment with rhynchophylline or ketamine, the time of staying in methamphetamine-paired compartment of rats was significantly reduced. Methamphetamine also increased the number of p-CREB positive cells in the striatum and hippocampal CA1 zone, as well as p-Fos positive cells. However, the compound Rhy could attenuate the effect. These findings show that Rhy can suppress the acquisition of CPP in rats induced by methamphetamine and the action may be related with the reduced expression of p-CREB and p-Fos in the striatum and hippocampus.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalFitoterapia
Volume92
Issue number1
DOIs
Publication statusPublished - Jan 2014

Scopus Subject Areas

  • Pharmacology
  • Drug Discovery

User-Defined Keywords

  • c-Fos
  • Conditioned place preference
  • Methamphetamine
  • p-CREB
  • Rhynchophylline

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