Efavirenz use and neurocognitive performance among older people living with HIV who were on antiretroviral therapy

Pei Qin; Jianmei He; Zixin Wang; Xi Chen; Jinghua Li; Ada Wai Tung Fung; Hui Jiang; Jie Chen; Anna Wong; Joseph Tak Fai Lau

doi:10.1080/09540121.2019.1622645

Efavirenz use and neurocognitive performance among older people living with HIV who were on antiretroviral therapy

Pei Qin
, Jianmei He
, Zixin Wang^*
, Xi Chen
, Jinghua Li
, Ada Wai Tung Fung
, Hui Jiang
, Jie Chen
, Anna Wong
, Joseph Tak Fai Lau^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

10 Citations (Scopus)

Abstract

This study was to compare global and domain-specific neurocognitive performance between older people living with HIV (PLWH) taking/not taking efavirenz (EFV) and HIV-negative controls. A cross-sectional study was conducted in Yongzhou city, China. All PLWH older than 50 years listed on the registry of Centres for Disease Control and Prevention were invited to join the study. Frequency matching was used to sample HIV-negative controls according to the distribution of age, sex, and years of formal education of older PLWH. A total of 308 older PLWH and 350 HIV-negative controls completed the face-to-face interview and neurocognitive assessment using the comprehensive neuropsychological test battery. After adjusting for significant confounders, older PLWH taking EFV showed poorer performance in memory (p = 0.020), verbal fluency (p = 0.002), and poorer global neurocognitive performance (p = 0.032) than those without EFV use. Compared to HIV-negative controls, older PLWH taking EFV had poorer performance in all neurocognitive domains (p values:

Original language	English
Pages (from-to)	12-20
Number of pages	9
Journal	AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV
Volume	32
Issue number	1
Early online date	30 May 2019
DOIs	https://doi.org/10.1080/09540121.2019.1622645
Publication status	Published - 2 Jan 2020

User-Defined Keywords

Neurocognitive performance
older people living with HIV
Efavirenz use
China

UN SDGs

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10.1080/09540121.2019.1622645

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title = "Efavirenz use and neurocognitive performance among older people living with HIV who were on antiretroviral therapy",

abstract = "This study was to compare global and domain-specific neurocognitive performance between older people living with HIV (PLWH) taking/not taking efavirenz (EFV) and HIV-negative controls. A cross-sectional study was conducted in Yongzhou city, China. All PLWH older than 50 years listed on the registry of Centres for Disease Control and Prevention were invited to join the study. Frequency matching was used to sample HIV-negative controls according to the distribution of age, sex, and years of formal education of older PLWH. A total of 308 older PLWH and 350 HIV-negative controls completed the face-to-face interview and neurocognitive assessment using the comprehensive neuropsychological test battery. After adjusting for significant confounders, older PLWH taking EFV showed poorer performance in memory (p = 0.020), verbal fluency (p = 0.002), and poorer global neurocognitive performance (p = 0.032) than those without EFV use. Compared to HIV-negative controls, older PLWH taking EFV had poorer performance in all neurocognitive domains (p values: ",

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author = "Pei Qin and Jianmei He and Zixin Wang and Xi Chen and Jinghua Li and Fung, \{Ada Wai Tung\} and Hui Jiang and Jie Chen and Anna Wong and Lau, \{Joseph Tak Fai\}",

note = "Funding information: This work was supported by Health and Family Planning Commission in the Hunan Province, China [grant number C2016031]. Publisher copyright: {\textcopyright} 2019 Informa UK Limited, trading as Taylor \& Francis Group",

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AU - Qin, Pei

AU - He, Jianmei

AU - Wang, Zixin

AU - Chen, Xi

AU - Li, Jinghua

AU - Fung, Ada Wai Tung

AU - Jiang, Hui

AU - Chen, Jie

AU - Wong, Anna

AU - Lau, Joseph Tak Fai

N1 - Funding information: This work was supported by Health and Family Planning Commission in the Hunan Province, China [grant number C2016031]. Publisher copyright: © 2019 Informa UK Limited, trading as Taylor & Francis Group

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N2 - This study was to compare global and domain-specific neurocognitive performance between older people living with HIV (PLWH) taking/not taking efavirenz (EFV) and HIV-negative controls. A cross-sectional study was conducted in Yongzhou city, China. All PLWH older than 50 years listed on the registry of Centres for Disease Control and Prevention were invited to join the study. Frequency matching was used to sample HIV-negative controls according to the distribution of age, sex, and years of formal education of older PLWH. A total of 308 older PLWH and 350 HIV-negative controls completed the face-to-face interview and neurocognitive assessment using the comprehensive neuropsychological test battery. After adjusting for significant confounders, older PLWH taking EFV showed poorer performance in memory (p = 0.020), verbal fluency (p = 0.002), and poorer global neurocognitive performance (p = 0.032) than those without EFV use. Compared to HIV-negative controls, older PLWH taking EFV had poorer performance in all neurocognitive domains (p values:

AB - This study was to compare global and domain-specific neurocognitive performance between older people living with HIV (PLWH) taking/not taking efavirenz (EFV) and HIV-negative controls. A cross-sectional study was conducted in Yongzhou city, China. All PLWH older than 50 years listed on the registry of Centres for Disease Control and Prevention were invited to join the study. Frequency matching was used to sample HIV-negative controls according to the distribution of age, sex, and years of formal education of older PLWH. A total of 308 older PLWH and 350 HIV-negative controls completed the face-to-face interview and neurocognitive assessment using the comprehensive neuropsychological test battery. After adjusting for significant confounders, older PLWH taking EFV showed poorer performance in memory (p = 0.020), verbal fluency (p = 0.002), and poorer global neurocognitive performance (p = 0.032) than those without EFV use. Compared to HIV-negative controls, older PLWH taking EFV had poorer performance in all neurocognitive domains (p values:

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Efavirenz use and neurocognitive performance among older people living with HIV who were on antiretroviral therapy

Abstract

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