TY - JOUR
T1 - Efavirenz use and neurocognitive performance among older people living with HIV who were on antiretroviral therapy
AU - Qin, Pei
AU - He, Jianmei
AU - Wang, Zixin
AU - Chen, Xi
AU - Li, Jinghua
AU - Fung, Ada Wai Tung
AU - Jiang, Hui
AU - Chen, Jie
AU - Wong, Anna
AU - Lau, Joseph Tak Fai
N1 - Funding information:
This work was supported by Health and Family Planning Commission in the Hunan Province, China [grant number C2016031].
Publisher copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group
PY - 2020/1/2
Y1 - 2020/1/2
N2 - This study was to compare global and domain-specific neurocognitive performance between older people living with HIV (PLWH) taking/not taking efavirenz (EFV) and HIV-negative controls. A cross-sectional study was conducted in Yongzhou city, China. All PLWH older than 50 years listed on the registry of Centres for Disease Control and Prevention were invited to join the study. Frequency matching was used to sample HIV-negative controls according to the distribution of age, sex, and years of formal education of older PLWH. A total of 308 older PLWH and 350 HIV-negative controls completed the face-to-face interview and neurocognitive assessment using the comprehensive neuropsychological test battery. After adjusting for significant confounders, older PLWH taking EFV showed poorer performance in memory (p = 0.020), verbal fluency (p = 0.002), and poorer global neurocognitive performance (p = 0.032) than those without EFV use. Compared to HIV-negative controls, older PLWH taking EFV had poorer performance in all neurocognitive domains (p values:
AB - This study was to compare global and domain-specific neurocognitive performance between older people living with HIV (PLWH) taking/not taking efavirenz (EFV) and HIV-negative controls. A cross-sectional study was conducted in Yongzhou city, China. All PLWH older than 50 years listed on the registry of Centres for Disease Control and Prevention were invited to join the study. Frequency matching was used to sample HIV-negative controls according to the distribution of age, sex, and years of formal education of older PLWH. A total of 308 older PLWH and 350 HIV-negative controls completed the face-to-face interview and neurocognitive assessment using the comprehensive neuropsychological test battery. After adjusting for significant confounders, older PLWH taking EFV showed poorer performance in memory (p = 0.020), verbal fluency (p = 0.002), and poorer global neurocognitive performance (p = 0.032) than those without EFV use. Compared to HIV-negative controls, older PLWH taking EFV had poorer performance in all neurocognitive domains (p values:
KW - Neurocognitive performance
KW - older people living with HIV
KW - Efavirenz use
KW - China
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067655236&doi=10.1080%2f09540121.2019.1622645&partnerID=40&md5=626412f39e0c0a1530bafd37fe335742
U2 - 10.1080/09540121.2019.1622645
DO - 10.1080/09540121.2019.1622645
M3 - Journal article
SN - 0954-0121
VL - 32
SP - 12
EP - 20
JO - AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV
JF - AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV
IS - 1
ER -
