TY - JOUR
T1 - Edible plants from traditional Chinese medicine is a promising alternative for the management of diabetic nephropathy
AU - Liu, Jing Yi
AU - Chen, Xiao Xin
AU - Tang, Sydney Chi Wai
AU - Lao, Li Xing
AU - Sze, Stephen Cho Wing
AU - Lee, Kai Fai
AU - Zhang, Kalin Yan Bo
N1 - Funding information:
This study was supported by grants from Seed Funding Programme for Basic Research from HKU (Project No. 201111159043); the Innovation and Technology Support Programme (Project code: ITS/313/11); and the Government of Hong Kong Special Administrative Region. The founders had no role in the design, analysis or writing of this article. We also thank Dr. James Chung-Man Ho and Dr. Tzi-Bun Ng from the Faculty of Medicine, The University of Hong Kong for giving us constructive advice and useful comments both during the preparation and submission of the manuscript. All authors contributed to the collection of data for the article, discussion of the content, writing and editing of the manuscript before submission. The authors have no conflicts of interest to declare.
Publisher copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/4
Y1 - 2015/4
N2 - Diabetic nephropathy (DN) is a serious microvascular complication in diabetes mellitus patients and 30–45% of DN patients progresses to end-stage renal disease, imposing a heavy burden on the society. Unfortunately, the pathogenesis of DN remains unclear, and effective and safe therapies are in great demand. Rather than conventional medicines that concentrate on delaying renal failure by controlling blood sugar and/or ameliorating microalbuminuria, traditional Chinese medicine (TCM) emphasize on the patients' whole inner system and devote to repair the kidney with consideration of overall health. Since many TCM herbs are edible, edible plants from TCM as diet therapy would be a promising alternative for DN management. To date, remarkable progresses have been made on the therapeutic effects of TCM edible plants for DN. In this review, the pathogenesis and experimental models of DN are firstly discussed. Thereafter, the structures of active components from TCM edible plants are summarized followed by discussion of recent research on TCM edible plants as functional food for diet therapy. Additionally, the necessity for safety evaluation of TCM edible plants for DN treatment is addressed.
AB - Diabetic nephropathy (DN) is a serious microvascular complication in diabetes mellitus patients and 30–45% of DN patients progresses to end-stage renal disease, imposing a heavy burden on the society. Unfortunately, the pathogenesis of DN remains unclear, and effective and safe therapies are in great demand. Rather than conventional medicines that concentrate on delaying renal failure by controlling blood sugar and/or ameliorating microalbuminuria, traditional Chinese medicine (TCM) emphasize on the patients' whole inner system and devote to repair the kidney with consideration of overall health. Since many TCM herbs are edible, edible plants from TCM as diet therapy would be a promising alternative for DN management. To date, remarkable progresses have been made on the therapeutic effects of TCM edible plants for DN. In this review, the pathogenesis and experimental models of DN are firstly discussed. Thereafter, the structures of active components from TCM edible plants are summarized followed by discussion of recent research on TCM edible plants as functional food for diet therapy. Additionally, the necessity for safety evaluation of TCM edible plants for DN treatment is addressed.
KW - Diabetic nephropathy
KW - Traditional Chinese medicine
KW - Edible plants
KW - Active components
KW - Diet therapy
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84926334619&partnerID=MN8TOARS
U2 - 10.1016/j.jff.2015.01.034
DO - 10.1016/j.jff.2015.01.034
M3 - Journal article
SN - 1756-4646
VL - 14
SP - 12
EP - 22
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -
