EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Lijun Jiang; Yin Lai Lui; Hongguang Li; Chi Fai Chan; Rongfeng Lan; Wai Lun Chan; Terrence Chi Kong Lau; George Sai Wah Tsao; Nak Ki Mak; Ka Leung Wong

doi:10.1039/c4cc01589d

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Lijun Jiang, Yin Lai Lui, Hongguang Li, Chi Fai Chan, Rongfeng Lan, Wai Lun Chan, Terrence Chi Kong Lau, George Sai Wah Tsao, Nak Ki Mak^*, Ka Leung Wong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

An EBNA1-specific small molecule (JLP₂) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP₂ may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.

Original language	English
Pages (from-to)	6517-6519
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	49
Early online date	28 Mar 2014
DOIs	https://doi.org/10.1039/c4cc01589d
Publication status	Published - 21 Jun 2014

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c4cc01589d

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title = "EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells",

abstract = "An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.",

author = "Lijun Jiang and Lui, {Yin Lai} and Hongguang Li and Chan, {Chi Fai} and Rongfeng Lan and Chan, {Wai Lun} and Lau, {Terrence Chi Kong} and Tsao, {George Sai Wah} and Mak, {Nak Ki} and Wong, {Ka Leung}",

note = "Funding information: This work was funded by grants from The Hong Kong Research Grants Council (HKBU 203013), City University of Hong Kong, and Hong Kong Baptist University (FRG 2/12-13/069). Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2014",

year = "2014",

month = jun,

day = "21",

doi = "10.1039/c4cc01589d",

language = "English",

volume = "50",

pages = "6517--6519",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "49",

}

TY - JOUR

T1 - EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

AU - Jiang, Lijun

AU - Lui, Yin Lai

AU - Li, Hongguang

AU - Chan, Chi Fai

AU - Lan, Rongfeng

AU - Chan, Wai Lun

AU - Lau, Terrence Chi Kong

AU - Tsao, George Sai Wah

AU - Mak, Nak Ki

AU - Wong, Ka Leung

N1 - Funding information: This work was funded by grants from The Hong Kong Research Grants Council (HKBU 203013), City University of Hong Kong, and Hong Kong Baptist University (FRG 2/12-13/069). Publisher copyright: © The Royal Society of Chemistry 2014

PY - 2014/6/21

Y1 - 2014/6/21

N2 - An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.

AB - An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.

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U2 - 10.1039/c4cc01589d

DO - 10.1039/c4cc01589d

M3 - Article

C2 - 24821080

AN - SCOPUS:84901374691

SN - 1359-7345

VL - 50

SP - 6517

EP - 6519

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Abstract

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