EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells

Lijun Jiang, Yin Lai Lui, Hongguang Li, Chi Fai Chan, Rongfeng Lan, Wai Lun Chan, Terrence Chi-Kong Lau, George Sai-Wah Tsao, Nai Ki MAK, Ka-Leung WONG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.

Original languageEnglish
Pages (from-to)6517-6519
Number of pages3
JournalChemical Communications
Volume50
Issue number49
DOIs
Publication statusPublished - 22 May 2014

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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