TY - JOUR
T1 - Early-life exposure to endocrine disrupting chemicals associates with childhood obesity
AU - Yang, Chunxue
AU - Lee, Hin Kiu
AU - Kong, Alice Pik Shan
AU - Lim, Lee Ling
AU - Cai, Zongwei
AU - Chung, Chi Kong Arthur
N1 - Funding Information:
This work was supported by the grants from Mr. Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund, Hong Kong Baptist University; National Natural Science Foundation of China (General Program 21577115 and 21477101); the Research Grant Council of Hong Kong (RGC GRF 463612, 14104314, 12300114); Faculty Research Grants from the Hong Kong Baptist University (FRG2/15-16/067; FRG2/16-17/049; FRG2/17-18/072); Hong Kong Health and Medical Research Fund (HMRF/ 03144376); and HKASO research grant 2015-16.
PY - 2018/12
Y1 - 2018/12
N2 - Increasing prevalence of childhood obesity poses threats to the global health burden. Because this rising prevalence cannot be fully explained by traditional risk factors such as unhealthy diet and physical inactivity, early-life exposure to endocrine disrupting chemicals (EDCs) is recognized as emerging novel risk factors for childhood obesity. EDCs can disrupt the hormone-mediated metabolic pathways, affect children’s growth and mediate the development of childhood obesity. Many organic pollutants are recently classified to be EDCs. In this review, we summarized the epidemiological and laboratory evidence related to EDCs and childhood obesity, and discussed the possible mechanisms underpinning childhood obesity and early-life exposure to non-persistent organic pollutants (phthalates, bisphenol A, triclosan) and persistent organic pollutants (dichlorodiphenyltrichloroethane, polychlorinated biphenyls, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances). Understanding the relationship between EDCs and childhood obesity helps to raise public awareness and formulate public health policy to protect the youth from exposure to the harmful effects of EDCs.
AB - Increasing prevalence of childhood obesity poses threats to the global health burden. Because this rising prevalence cannot be fully explained by traditional risk factors such as unhealthy diet and physical inactivity, early-life exposure to endocrine disrupting chemicals (EDCs) is recognized as emerging novel risk factors for childhood obesity. EDCs can disrupt the hormone-mediated metabolic pathways, affect children’s growth and mediate the development of childhood obesity. Many organic pollutants are recently classified to be EDCs. In this review, we summarized the epidemiological and laboratory evidence related to EDCs and childhood obesity, and discussed the possible mechanisms underpinning childhood obesity and early-life exposure to non-persistent organic pollutants (phthalates, bisphenol A, triclosan) and persistent organic pollutants (dichlorodiphenyltrichloroethane, polychlorinated biphenyls, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances). Understanding the relationship between EDCs and childhood obesity helps to raise public awareness and formulate public health policy to protect the youth from exposure to the harmful effects of EDCs.
KW - Childhood obesity
KW - Early-life exposure
KW - Endocrine disrupting chemicals
KW - Persistent organic pollutants
UR - http://www.scopus.com/inward/record.url?scp=85063908744&partnerID=8YFLogxK
U2 - 10.6065/apem.2018.23.4.182
DO - 10.6065/apem.2018.23.4.182
M3 - Review article
AN - SCOPUS:85063908744
SN - 2287-1012
VL - 23
SP - 182
EP - 195
JO - Annals of Pediatric Endocrinology and Metabolism
JF - Annals of Pediatric Endocrinology and Metabolism
IS - 4
ER -
