Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma

Sarwat Fatima; John M. Luk; Ronnie T.P. Poon; Nikki P. Lee

doi:10.1586/14737159.2014.915747

Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma

Sarwat Fatima, John M. Luk, Ronnie T.P. Poon, Nikki P. Lee^*

^*Corresponding author for this work

Chinese Medicine - Clinical Division

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

The prognosis for hepatocellular carcinoma (HCC) remains dismal due to the lack of diagnostic markers for early detection. This review will discuss the clinical potential of the dickkopf (DKK) family members as diagnostic and/or prognostic markers for HCC. In comparison to serum α-fetoprotein (AFP) level, which remains the gold standard for HCC diagnosis, high serum DKK1 levels have higher diagnostic value for HCC, especially for AFP-negative HCC, and can distinguish HCC from non-malignant chronic liver diseases. Additionally, the combination of serum DKK1 and AFP levels enhances diagnostic accuracy for HCC compared to serum DKK1 or AFP levels alone. Although DKK1 offers potential for its use in HCC diagnosis this review will discuss the challenges facing DKK1 and also shed some light on recent developments on the remaining DKK family members: DKK2, DKK3 and DKK4.

Original language	English
Pages (from-to)	535-548
Number of pages	14
Journal	Expert Review of Molecular Diagnostics
Volume	14
Issue number	5
DOIs	https://doi.org/10.1586/14737159.2014.915747
Publication status	Published - Jun 2014

Scopus Subject Areas

Pathology and Forensic Medicine
Molecular Medicine
Molecular Biology
Genetics

User-Defined Keywords

AFP
Diagnosis
Dickkopfs
Hepatocellular carcinoma
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1586/14737159.2014.915747

Cite this

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title = "Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma",

abstract = "The prognosis for hepatocellular carcinoma (HCC) remains dismal due to the lack of diagnostic markers for early detection. This review will discuss the clinical potential of the dickkopf (DKK) family members as diagnostic and/or prognostic markers for HCC. In comparison to serum α-fetoprotein (AFP) level, which remains the gold standard for HCC diagnosis, high serum DKK1 levels have higher diagnostic value for HCC, especially for AFP-negative HCC, and can distinguish HCC from non-malignant chronic liver diseases. Additionally, the combination of serum DKK1 and AFP levels enhances diagnostic accuracy for HCC compared to serum DKK1 or AFP levels alone. Although DKK1 offers potential for its use in HCC diagnosis this review will discuss the challenges facing DKK1 and also shed some light on recent developments on the remaining DKK family members: DKK2, DKK3 and DKK4.",

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author = "Sarwat Fatima and Luk, {John M.} and Poon, {Ronnie T.P.} and Lee, {Nikki P.}",

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T1 - Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma

AU - Fatima, Sarwat

AU - Luk, John M.

AU - Poon, Ronnie T.P.

AU - Lee, Nikki P.

PY - 2014/6

Y1 - 2014/6

N2 - The prognosis for hepatocellular carcinoma (HCC) remains dismal due to the lack of diagnostic markers for early detection. This review will discuss the clinical potential of the dickkopf (DKK) family members as diagnostic and/or prognostic markers for HCC. In comparison to serum α-fetoprotein (AFP) level, which remains the gold standard for HCC diagnosis, high serum DKK1 levels have higher diagnostic value for HCC, especially for AFP-negative HCC, and can distinguish HCC from non-malignant chronic liver diseases. Additionally, the combination of serum DKK1 and AFP levels enhances diagnostic accuracy for HCC compared to serum DKK1 or AFP levels alone. Although DKK1 offers potential for its use in HCC diagnosis this review will discuss the challenges facing DKK1 and also shed some light on recent developments on the remaining DKK family members: DKK2, DKK3 and DKK4.

AB - The prognosis for hepatocellular carcinoma (HCC) remains dismal due to the lack of diagnostic markers for early detection. This review will discuss the clinical potential of the dickkopf (DKK) family members as diagnostic and/or prognostic markers for HCC. In comparison to serum α-fetoprotein (AFP) level, which remains the gold standard for HCC diagnosis, high serum DKK1 levels have higher diagnostic value for HCC, especially for AFP-negative HCC, and can distinguish HCC from non-malignant chronic liver diseases. Additionally, the combination of serum DKK1 and AFP levels enhances diagnostic accuracy for HCC compared to serum DKK1 or AFP levels alone. Although DKK1 offers potential for its use in HCC diagnosis this review will discuss the challenges facing DKK1 and also shed some light on recent developments on the remaining DKK family members: DKK2, DKK3 and DKK4.

KW - AFP

KW - Diagnosis

KW - Dickkopfs

KW - Hepatocellular carcinoma

KW - Prognosis

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Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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