Dynamics-Evolution Correspondence in Protein Structures

Qian Yuan Tang*, Kunihiko Kaneko*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

16 Citations (Scopus)

Abstract

The genotype-phenotype mapping of proteins is a fundamental question in structural biology. In this Letter, with the analysis of a large dataset of proteins from hundreds of protein families, we quantitatively demonstrate the correlations between the noise-induced protein dynamics and mutation-induced variations of native structures, indicating the dynamics-evolution correspondence of proteins. Based on the investigations of the linear responses of native proteins, the origin of such a correspondence is elucidated. It is essential that the noise- and mutation-induced deformations of the proteins are restricted on a common low-dimensional subspace, as confirmed from the data. These results suggest an evolutionary mechanism of the proteins gaining both dynamical flexibility and evolutionary structural variability.

Original languageEnglish
Article number098103
Number of pages8
JournalPhysical Review Letters
Volume127
Issue number9
DOIs
Publication statusPublished - 27 Aug 2021
Externally publishedYes

Scopus Subject Areas

  • Physics and Astronomy(all)

Fingerprint

Dive into the research topics of 'Dynamics-Evolution Correspondence in Protein Structures'. Together they form a unique fingerprint.

Cite this