Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF 5:Yb/Er

Songjun Zeng; Ming Kiu Tsang; Chi Fai Chan; Ka Leung Wong; Bin Fei; Jianhua Hao

doi:10.1039/c2nr31294h

Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF ₅:Yb/Er

Songjun Zeng, Ming Kiu Tsang, Chi Fai Chan, Ka Leung Wong, Bin Fei, Jianhua Hao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

98 Citations (Scopus)

Abstract

A new type of BaGdF ₅:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF ₅:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF ₅:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF ₅:Yb/Er NPs. Moreover, these BaGdF ₅ NPs exhibit excellent intrinsic paramagnetic properties and enhanced T ₁-weighted MRI images with increased concentrations of BaGdF ₅ NPs. Therefore, these results suggest that the amine-functionalized BaGdF ₅ NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI.

Original language	English
Pages (from-to)	5118-5124
Number of pages	7
Journal	Nanoscale
Volume	4
Issue number	16
DOIs	https://doi.org/10.1039/c2nr31294h
Publication status	Published - 21 Aug 2012

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General Materials Science

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@article{b28580523eba4c67ab86d4fbaf0765a3,

title = "Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF 5:Yb/Er",

abstract = "A new type of BaGdF 5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF 5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF 5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF 5:Yb/Er NPs. Moreover, these BaGdF 5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T 1-weighted MRI images with increased concentrations of BaGdF 5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF 5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI.",

author = "Songjun Zeng and Tsang, {Ming Kiu} and Chan, {Chi Fai} and Wong, {Ka Leung} and Bin Fei and Jianhua Hao",

year = "2012",

month = aug,

day = "21",

doi = "10.1039/c2nr31294h",

language = "English",

volume = "4",

pages = "5118--5124",

journal = "Nanoscale",

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publisher = "Royal Society of Chemistry",

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T1 - Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF 5:Yb/Er

AU - Zeng, Songjun

AU - Tsang, Ming Kiu

AU - Chan, Chi Fai

AU - Wong, Ka Leung

AU - Fei, Bin

AU - Hao, Jianhua

PY - 2012/8/21

Y1 - 2012/8/21

N2 - A new type of BaGdF 5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF 5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF 5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF 5:Yb/Er NPs. Moreover, these BaGdF 5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T 1-weighted MRI images with increased concentrations of BaGdF 5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF 5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI.

AB - A new type of BaGdF 5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF 5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF 5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF 5:Yb/Er NPs. Moreover, these BaGdF 5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T 1-weighted MRI images with increased concentrations of BaGdF 5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF 5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI.

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SN - 2040-3364

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SP - 5118

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JO - Nanoscale

JF - Nanoscale

IS - 16

ER -

Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF ₅:Yb/Er

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