Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(iii) complex

Chun Yuen Wong; Lai Hon Chung; Lihua Lu; Modi Wang; Bingyong He; Li Juan Liu; Chung Hang Leung; Dik Lung Ma

doi:10.2174/1567205012666150504144558

Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(iii) complex

Chun Yuen Wong^*
, Lai Hon Chung
, Lihua Lu
, Modi Wang
, Bingyong He
, Li Juan Liu
, Chung Hang Leung
, Dik Lung Ma

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

29 Citations (Scopus)

Abstract

In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

Original language	English
Pages (from-to)	439-444
Number of pages	6
Journal	Current Alzheimer Research
Volume	12
Issue number	5
DOIs	https://doi.org/10.2174/1567205012666150504144558
Publication status	Published - 2015

User-Defined Keywords

Aggregation
Alzheimer's
Amyloid
Iridium
Luminescent probe

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10.2174/1567205012666150504144558

Cite this

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title = "Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(iii) complex",

abstract = "In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C\textasciicircum{}C\textasciicircum{}C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer{\textquoteright}s disease diagnosis and treatment.",

keywords = "Aggregation, Alzheimer's, Amyloid, Iridium, Luminescent probe",

author = "Wong, \{Chun Yuen\} and Chung, \{Lai Hon\} and Lihua Lu and Modi Wang and Bingyong He and Liu, \{Li Juan\} and Leung, \{Chung Hang\} and Ma, \{Dik Lung\}",

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doi = "10.2174/1567205012666150504144558",

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T1 - Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(iii) complex

AU - Wong, Chun Yuen

AU - Chung, Lai Hon

AU - Lu, Lihua

AU - Wang, Modi

AU - He, Bingyong

AU - Liu, Li Juan

AU - Leung, Chung Hang

AU - Ma, Dik Lung

PY - 2015

Y1 - 2015

N2 - In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

AB - In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

KW - Aggregation

KW - Alzheimer's

KW - Amyloid

KW - Iridium

KW - Luminescent probe

UR - https://www.scopus.com/pages/publications/84930891349

U2 - 10.2174/1567205012666150504144558

DO - 10.2174/1567205012666150504144558

M3 - Journal article

C2 - 25938873

AN - SCOPUS:84930891349

SN - 1567-2050

VL - 12

SP - 439

EP - 444

JO - Current Alzheimer Research

JF - Current Alzheimer Research

IS - 5

ER -

Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(iii) complex

Abstract

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