Abstract
In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.
Original language | English |
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Pages (from-to) | 439-444 |
Number of pages | 6 |
Journal | Current Alzheimer Research |
Volume | 12 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2015 |
Scopus Subject Areas
- Neurology
- Clinical Neurology
User-Defined Keywords
- Aggregation
- Alzheimer's
- Amyloid
- Iridium
- Luminescent probe