Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(iii) complex

Chun Yuen Wong*, Lai Hon Chung, Lihua Lu, Modi Wang, Bingyong He, Li Juan Liu, Chung Hang Leung, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalCurrent Alzheimer Research
Volume12
Issue number5
DOIs
Publication statusPublished - 2015

Scopus Subject Areas

  • Neurology
  • Clinical Neurology

User-Defined Keywords

  • Aggregation
  • Alzheimer's
  • Amyloid
  • Iridium
  • Luminescent probe

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