Dual Fiber-In-capillary Annular Column with Ternary Stationary Phase for Gas Chromatographic Separation

Wenxi Qiu, Peiyu Diao, Hongyan Yuan, Dan Xiao*, Martin M F CHOI

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In the present work a novel strategy for improving and/or tuning the selectivity of gas chromatographic (GC) separation by combining three different stationary phases (SPs) without premixing was introduced. A fused silica fiber coated with polydimethylsiloxane (SE30) and another coated with cyanopropylphenylmethylpolysiloxane (OV1701) were serially inserted into an 8-m polyethylene glycol 20 M (PEG20M) capillary column to form a GC annular column with ternary SP, abbreviating as SE30-OV1701-CF/PEG20M-CC. The separation capability of this ternary SP annular column was compared with a SE30-coated fiber-in-PEG20M-coated capillary annular column and a PEG20M-coated open tubular column by a test mixture of 19 organic compounds. Among these three columns, SE30-OV1701-CF/PEG20M-CC produced the best separation when the SE30-coated fiber and OV1701-coated fiber was 3 and 5 m, respectively. Selectivity can be easily tuned by changing the length of the SP-coated fibers in the ternary SP annular column. The proposed ternary SP annular column shows additional tunability, thus making it a promising tool for separation of organic solvents that are often used in the manufacturing process of pharmaceutical formulations and lacquer thinners.

Original languageEnglish
Pages (from-to)2721-2731
Number of pages11
JournalAnalytical Letters
Volume44
Issue number16
DOIs
Publication statusPublished - Nov 2011

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry

User-Defined Keywords

  • Dual fiber
  • Gas chromatography
  • Selectivity
  • Ternary stationary phase

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