Dual-Defect Abundant Graphitic Carbon Nitride for Efficient Photocatalytic Nicotinamide Cofactor Regeneration

Fengjia Xie, Huaping Jia, Ching Kit Tommy Wun, Xiaowen Huang, Yao Chai, Chi Chung Tsoi, Zhefei Pan, Shunni Zhu, Kangning Ren, Tsz Woon Benedict Lo, Yujiao Zhu*, Xuming Zhang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

Photocatalytic regeneration of valuable cofactors by using sunlight has emerged as a promising strategy for biosynthesis and pharmaceutical manufacturing. Graphitic carbon nitride (g-C3N4) is very suitable for photocatalytic nicotinamide cofactor regeneration since it is metal-free, visible-light responsive and has strong binding with nicotinamide cofactor. However, its great potential is hindered by some intrinsic drawbacks such as low visible absorption, fast electron/hole recombination, and limited active sites. Here, we demonstrate dual-defect g-C3N4 (DDCN) with controllable defects of nitrogen vacancies and cyano groups for efficient photocatalytic cofactor regeneration via a KOH-assisted thermal polymerization by using urea as a precursor. Although DDCN is widely used for other photocatalytic applications such as organic degradation and hydrogen peroxide production, this work is original in its application to photocatalytic cofactor regeneration. Material characterizations confirm the successful introduction of nitrogen vacancies and cyano groups. Measurements of nicotinamide-cofactor generation show that the DDCN samples assisted with 0.1 g and 0.01 g KOH are 3.0 and 2.5 times that of pristine g-C3N4 in terms of nicotinamide cofactor yield, respectively. The high yields are attributed to the synergetic effect of both enhanced light absorption and improved charge separation, achieved through the introduction of energy levels and trap states via dual defects. This work provides a green, energy-saving, and promising strategy for nicotinamide cofactor regeneration and would promote its application in biosynthesis and drug manufacturing.

Original languageEnglish
Pages (from-to)11002-11011
Number of pages10
JournalACS Sustainable Chemistry and Engineering
Volume11
Issue number30
Early online date18 Jul 2023
DOIs
Publication statusPublished - 31 Jul 2023

Scopus Subject Areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment

User-Defined Keywords

  • defective g-CN
  • graphitic carbon nitride
  • photocatalysis
  • photocatalytic cofactor regeneration
  • reduced nicotinamide adenine dinucleotide

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