Drug delivery system targeting advanced hepatocellular carcinoma: Current and future

Xue Zhang, Huei Leng Helena Ng, Aiping LYU, Congcong Lin, Limin ZHOU, Ge Lin, Yanbo Zhang, Zhijun YANG*, Hong Qi ZHANG*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

96 Citations (Scopus)


Hepatocellular carcinoma (HCC) has a fairly high morbidity and is notoriously difficult to treat due to long latent period before detection, multidrug resistance and severe drug-related adverse effects from chemotherapy. Targeted drug delivery systems (DDS) that can selectively deliver therapeutic drugs into tumor sites have demonstrated a great potential in cancer treatment, which could be utilized to resolve the limitations of conventional chemotherapy. Numerous preclinical studies of DDS have been published, but targeted DDS for HCC has yet to be made for practical clinical use. Since rational targeted DDS design should take cancer-specific properties into consideration, we have reviewed the biological and physicochemical properties of HCC extensively to provide a comprehensive understanding on HCC, and recent DDS studies on HCC, aiming to find some potential targeted DDSs for HCC treatment and a meaningful platform for further development of HCC treatments.

Original languageEnglish
Pages (from-to)853-869
Number of pages17
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Issue number4
Publication statusPublished - May 2016

Scopus Subject Areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

User-Defined Keywords

  • Advanced hepatocellular carcinoma
  • Liver cancer
  • Nanomedicine
  • Targeted drug delivery systems


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