TY - JOUR
T1 - Doxifluridine-based pharmacosomes delivering miR-122 as tumor microenvironments-activated nanoplatforms for synergistic treatment of hepatocellular carcinoma
AU - Xue, Fangqin
AU - Lin, Xiao
AU - Cai, Zhixiong
AU - Liu, Xiaolong
AU - Ma, Yuan
AU - Wu, Ming
N1 - Funding Information:
This work was supported by the Science and Technology General Program of Fujian Province (Grant No. 2018J01263), the Special Funds of Fujian Provincial Department of Finance (Grant Nos. (2020)500#, (2018)710#), the joint research projects of Health and Education Commission of Fujian Province (Grant No. 2019-WJ-20), the Joint Funds for the Innovation of Science and Technology, Fujian Province (Grant No. 2019Y9046).
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/1
Y1 - 2021/1
N2 - A novel kind of anti-cancer pharmacosome (named NPC-D) derived from Doxifluridine (5′-DFUR) was described, which could be activated by tumor microenvironments (TMEs). The NPC-D with H2O2-sensitive linker was dispersed well in water and simultaneously interacted with nucleic acids including plasmids encoding miR-122 (p122) and EpCAM-targeted aptamer (ap1) via charge interaction and hydrogen bonding. The integrated nanosystem (p122-ap1@NPC-D) was found to unleash by programmed TMEs (high level of H2O2 and low pH) to efficiently transfect miR-122 into MHCC-LM3 cells, followed by the releases of 5-FU. Besides, p122-ap1@NPC-D significantly countered the chemotherapy resistance and played a synergistic effect. These unique nanoparticles dramatically enhanced the anti-proliferation, and modulated the cellular apoptosis by the down-regulation of various signal pathways which imparted a bright application prospect in HCC treatment.
AB - A novel kind of anti-cancer pharmacosome (named NPC-D) derived from Doxifluridine (5′-DFUR) was described, which could be activated by tumor microenvironments (TMEs). The NPC-D with H2O2-sensitive linker was dispersed well in water and simultaneously interacted with nucleic acids including plasmids encoding miR-122 (p122) and EpCAM-targeted aptamer (ap1) via charge interaction and hydrogen bonding. The integrated nanosystem (p122-ap1@NPC-D) was found to unleash by programmed TMEs (high level of H2O2 and low pH) to efficiently transfect miR-122 into MHCC-LM3 cells, followed by the releases of 5-FU. Besides, p122-ap1@NPC-D significantly countered the chemotherapy resistance and played a synergistic effect. These unique nanoparticles dramatically enhanced the anti-proliferation, and modulated the cellular apoptosis by the down-regulation of various signal pathways which imparted a bright application prospect in HCC treatment.
KW - EpCAM-targeted aptamer
KW - miR-122
KW - Pharmacosome
KW - Synergistic anticancer effect
KW - Tumor microenvironments
UR - http://www.scopus.com/inward/record.url?scp=85091672170&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2020.111367
DO - 10.1016/j.colsurfb.2020.111367
M3 - Journal article
C2 - 33007506
AN - SCOPUS:85091672170
SN - 0927-7765
VL - 197
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
M1 - 111367
ER -
