Doped zinc sulfide quantum dots based phosphorescence turn-off/on probe for detecting histidine in biological fluid

Wei Bian; Fang Wang; Yanli Wei; Li Wang; Qiaoling Liu; Wenjuan Dong; Shaomin Shuang; Martin M.F. Choi

doi:10.1016/j.aca.2014.11.037

Doped zinc sulfide quantum dots based phosphorescence turn-off/on probe for detecting histidine in biological fluid

Wei Bian, Fang Wang, Yanli Wei, Li Wang, Qiaoling Liu, Wenjuan Dong, Shaomin Shuang^*, Martin M.F. Choi

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

38 Citations (Scopus)

Abstract

We report a turn-on phosphorescence probe for detection of histidine based on Co²⁺-adsorbed N-acetyl-l-cysteine (NAC) capped Mn: ZnS quantum dots (QDs) which is directly synthesized by the hydrothermal method. The phosphorescence of NAC-Mn: ZnS QDs is effectively quenched by Co²⁺ attributing to the adsorption of Co²⁺ onto the surface of QDs with a concomitant in suppressing the recombination process of hole and electron of QDs. The phosphorescence of Co²⁺-adsorbed NAC-Mn: ZnS QDs can be recovered by binding of Co²⁺ with histidine. The quenching and regeneration of the phosphorescence of NAC-Mn: ZnS QDs have been studied in detail. The as-prepared QDs-based probe is applied to determine histidine with a linear range of 1.25-30μM and a detection limit of 0.74μM. The relative standard deviation for eleven repeat detections of 20μM histidine is 0.65%. Co²⁺-adsorbed NAC-Mn: ZnS QDs show high sensitivity and good selectivity to histidine over other amino acids, metal ions and co-existing substances. The proposed QDs probe has been successfully applied to determination of histidine in human urine samples with good recoveries of 98.5-103%.

Original language	English
Pages (from-to)	82-89
Number of pages	8
Journal	Analytica Chimica Acta
Volume	856
DOIs	https://doi.org/10.1016/j.aca.2014.11.037
Publication status	Published - 26 Jan 2015

Scopus Subject Areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy

User-Defined Keywords

Biological fluids
Doped quantum dots
Histidine
Phosphorescence probe

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10.1016/j.aca.2014.11.037

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title = "Doped zinc sulfide quantum dots based phosphorescence turn-off/on probe for detecting histidine in biological fluid",

abstract = "We report a turn-on phosphorescence probe for detection of histidine based on Co2+-adsorbed N-acetyl-l-cysteine (NAC) capped Mn: ZnS quantum dots (QDs) which is directly synthesized by the hydrothermal method. The phosphorescence of NAC-Mn: ZnS QDs is effectively quenched by Co2+ attributing to the adsorption of Co2+ onto the surface of QDs with a concomitant in suppressing the recombination process of hole and electron of QDs. The phosphorescence of Co2+-adsorbed NAC-Mn: ZnS QDs can be recovered by binding of Co2+ with histidine. The quenching and regeneration of the phosphorescence of NAC-Mn: ZnS QDs have been studied in detail. The as-prepared QDs-based probe is applied to determine histidine with a linear range of 1.25-30μM and a detection limit of 0.74μM. The relative standard deviation for eleven repeat detections of 20μM histidine is 0.65%. Co2+-adsorbed NAC-Mn: ZnS QDs show high sensitivity and good selectivity to histidine over other amino acids, metal ions and co-existing substances. The proposed QDs probe has been successfully applied to determination of histidine in human urine samples with good recoveries of 98.5-103%.",

keywords = "Biological fluids, Doped quantum dots, Histidine, Phosphorescence probe",

author = "Wei Bian and Fang Wang and Yanli Wei and Li Wang and Qiaoling Liu and Wenjuan Dong and Shaomin Shuang and Choi, {Martin M.F.}",

note = "Funding Information: This work is supported by the Hundred Talent Programme of Shanxi Province, National Natural Science Foundation of China ( 21175086 ), Shanxi Medical University of Science and Technology Innovation Fund ( 01201312 ), and 331 Early Career Research Grant of Basic Medical College in Shanxi Medical University (201417). ",

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doi = "10.1016/j.aca.2014.11.037",

language = "English",

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journal = "Analytica Chimica Acta",

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T1 - Doped zinc sulfide quantum dots based phosphorescence turn-off/on probe for detecting histidine in biological fluid

AU - Bian, Wei

AU - Wang, Fang

AU - Wei, Yanli

AU - Wang, Li

AU - Liu, Qiaoling

AU - Dong, Wenjuan

AU - Shuang, Shaomin

AU - Choi, Martin M.F.

N1 - Funding Information: This work is supported by the Hundred Talent Programme of Shanxi Province, National Natural Science Foundation of China ( 21175086 ), Shanxi Medical University of Science and Technology Innovation Fund ( 01201312 ), and 331 Early Career Research Grant of Basic Medical College in Shanxi Medical University (201417).

PY - 2015/1/26

Y1 - 2015/1/26

N2 - We report a turn-on phosphorescence probe for detection of histidine based on Co2+-adsorbed N-acetyl-l-cysteine (NAC) capped Mn: ZnS quantum dots (QDs) which is directly synthesized by the hydrothermal method. The phosphorescence of NAC-Mn: ZnS QDs is effectively quenched by Co2+ attributing to the adsorption of Co2+ onto the surface of QDs with a concomitant in suppressing the recombination process of hole and electron of QDs. The phosphorescence of Co2+-adsorbed NAC-Mn: ZnS QDs can be recovered by binding of Co2+ with histidine. The quenching and regeneration of the phosphorescence of NAC-Mn: ZnS QDs have been studied in detail. The as-prepared QDs-based probe is applied to determine histidine with a linear range of 1.25-30μM and a detection limit of 0.74μM. The relative standard deviation for eleven repeat detections of 20μM histidine is 0.65%. Co2+-adsorbed NAC-Mn: ZnS QDs show high sensitivity and good selectivity to histidine over other amino acids, metal ions and co-existing substances. The proposed QDs probe has been successfully applied to determination of histidine in human urine samples with good recoveries of 98.5-103%.

AB - We report a turn-on phosphorescence probe for detection of histidine based on Co2+-adsorbed N-acetyl-l-cysteine (NAC) capped Mn: ZnS quantum dots (QDs) which is directly synthesized by the hydrothermal method. The phosphorescence of NAC-Mn: ZnS QDs is effectively quenched by Co2+ attributing to the adsorption of Co2+ onto the surface of QDs with a concomitant in suppressing the recombination process of hole and electron of QDs. The phosphorescence of Co2+-adsorbed NAC-Mn: ZnS QDs can be recovered by binding of Co2+ with histidine. The quenching and regeneration of the phosphorescence of NAC-Mn: ZnS QDs have been studied in detail. The as-prepared QDs-based probe is applied to determine histidine with a linear range of 1.25-30μM and a detection limit of 0.74μM. The relative standard deviation for eleven repeat detections of 20μM histidine is 0.65%. Co2+-adsorbed NAC-Mn: ZnS QDs show high sensitivity and good selectivity to histidine over other amino acids, metal ions and co-existing substances. The proposed QDs probe has been successfully applied to determination of histidine in human urine samples with good recoveries of 98.5-103%.

KW - Biological fluids

KW - Doped quantum dots

KW - Histidine

KW - Phosphorescence probe

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DO - 10.1016/j.aca.2014.11.037

M3 - Journal article

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AN - SCOPUS:84920437481

SN - 0003-2670

VL - 856

SP - 82

EP - 89

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

ER -

Doped zinc sulfide quantum dots based phosphorescence turn-off/on probe for detecting histidine in biological fluid

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