TY - JOUR
T1 - Does exercise beneficially affect sex hormones when added to hypo-caloric diets in adults with overweight or obesity? A systematic review and meta-analysis of controlled clinical trials
AU - Mohseni-Takalloo, Sahar
AU - Beigrezaei, Sara
AU - Yazdanpanah, Zeinab
AU - Hamide Rajaie, Seyede
AU - Soltani, Sepideh
AU - Zohrabi, Tayebeh
AU - Kaviani, Mojtaba
AU - Forbes, Scott C
AU - Baker, Julien S
AU - Salehi-Abargouei, Amin
N1 - Funding Information:
The present study was supported by the Research Council of the Nutrition
Publisher Copyright:
© European Society of Endocrinology 2022
PY - 2022/2
Y1 - 2022/2
N2 - ObjectiveThere is no consensus of opinion if exercise beneficially affects sex hormones if added to weight-loss diets. The purpose of this study was to perform a systematic review and meta-analysis of controlled clinical trials to evaluate the effect of adding exercise to a hypo-caloric diet during a weight-loss program, on serum testosterone, estradiol, and sex hormone-binding globulin (SHBG) in adults with overweight/obesity.DesignSystematic review and meta-analysis of the literature. MethodsOnline databases including PubMed/MEDLINE, EMBASE, Scopus, ISI Web of Science, and Google Scholar were searched up to April 2021. A random-effects model was applied to compare mean changes in sex hormones and SHBG between participants undergoing a hypo-caloric diet with or without exercise.ResultsIn total, 9 eligible clinical trials with 462 participants were included. Out of these, seven, three, and four studies illustrated changes in testosterone, estradiol, and SHBG, respectively. The meta-analysis revealed that exercise had no significant effect on circulating testosterone (WMD = −0.03 nmol/L, 95% CI: −0.11, 0.06, P = 0.51), estradiol (WMD = −0.46 pg/mL, 95% CI: −1.57, 0.65, P = 0.42), and SHBG (WMD = 0.54 nmol/L, 95% CI: −2.63, 3.71, P = 0.74) when added to low-calorie diets.ConclusionThe addition of exercise to a hypo-caloric diet provided no additional improvement in sex hormone profiles. Further, well-designed randomized controlled trials with longer follow-up periods in both sexes are recommended to confirm and expand the current results.
AB - ObjectiveThere is no consensus of opinion if exercise beneficially affects sex hormones if added to weight-loss diets. The purpose of this study was to perform a systematic review and meta-analysis of controlled clinical trials to evaluate the effect of adding exercise to a hypo-caloric diet during a weight-loss program, on serum testosterone, estradiol, and sex hormone-binding globulin (SHBG) in adults with overweight/obesity.DesignSystematic review and meta-analysis of the literature. MethodsOnline databases including PubMed/MEDLINE, EMBASE, Scopus, ISI Web of Science, and Google Scholar were searched up to April 2021. A random-effects model was applied to compare mean changes in sex hormones and SHBG between participants undergoing a hypo-caloric diet with or without exercise.ResultsIn total, 9 eligible clinical trials with 462 participants were included. Out of these, seven, three, and four studies illustrated changes in testosterone, estradiol, and SHBG, respectively. The meta-analysis revealed that exercise had no significant effect on circulating testosterone (WMD = −0.03 nmol/L, 95% CI: −0.11, 0.06, P = 0.51), estradiol (WMD = −0.46 pg/mL, 95% CI: −1.57, 0.65, P = 0.42), and SHBG (WMD = 0.54 nmol/L, 95% CI: −2.63, 3.71, P = 0.74) when added to low-calorie diets.ConclusionThe addition of exercise to a hypo-caloric diet provided no additional improvement in sex hormone profiles. Further, well-designed randomized controlled trials with longer follow-up periods in both sexes are recommended to confirm and expand the current results.
UR - http://www.scopus.com/inward/record.url?scp=85123388957&partnerID=8YFLogxK
U2 - 10.1530/EJE-21-0675
DO - 10.1530/EJE-21-0675
M3 - Review article
C2 - 34882579
AN - SCOPUS:85123388957
SN - 0804-4643
VL - 186
SP - 285
EP - 295
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 2
ER -