DNA-Hairpin-Templated Silver Nanoclusters: A Study on Stem Sequence

Yahui Guo, Fumiao Shen, Yuliang Cheng, Hang Yu, Yunfei Xie, Weirong Yao, Renjun Pei, He Qian, Hung Wing Li*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

18 Citations (Scopus)


DNA hairpins are widely used to synthesize silver nanoclusters (AgNCs) with excellent optical properties due to their specific secondary structure. Hairpin-AgNCs have been popularly employed for sensoring applications, while no systematic study has been done about the effect of stem sequence on the fluorescence property of hairpin-AgNCs. In this presented work, the synthesizing conditions of hairpin-AgNCs were fully examined first. Then, the effect of percentage content and distribution of GC base pairs as well as stem length on the fluorescence property of hairpin-AgNCs were studied. Intriguing phenomena were observed and basic conclusions were drawn, which would be helpful to understand the hairpin-AgNCs comprehensively and instructional for the applications using hairpin-AgNC probes.

Original languageEnglish
Pages (from-to)1592-1601
Number of pages10
JournalJournal of Physical Chemistry B
Issue number9
Publication statusPublished - 5 Mar 2020

Scopus Subject Areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry


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