Abstract
Nine new diterpenoids, melissoidesins M-U (1-9), along with five known analogues, melissoidesin F (10), xindongnin B (11), melissoidesin G (12), melissoidesin E (13), and dawoensin A (14), were isolated from the aerial parts of Isodon melissoides. The structures of new compounds were elucidated by analysis of spectral evidence including extensive 2D NMR data. Compounds 2, 3, 7, 11, 12, and 14 showed cytotoxicity against the human tumor BGC-823 cell line with IC50 values less than 10 μg/mL, respectively.
Original language | English |
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Pages (from-to) | 1441-1444 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 67 |
Issue number | 9 |
Early online date | 31 Jul 2004 |
DOIs | |
Publication status | Published - 1 Sept 2004 |
Scopus Subject Areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry