AIM: To study the chemical constituents of Isodon japonicus. METHOD: We isolated and elucidated the chemical constituents using chromatographic techniques and spectral analysis. RESULT and CONCLUSION: Twenty diterpenoids including three new eni-kauranoids (1-3) and a pair of epimers of new ent-abietanoid (4 and 5) were isolated and identified. These five new diterpenoids are 7β, 15β, 16β-trihydroxy-6β, 17-diacetoxy-7α, 20-epoxy-ent-kaurane (1) , 16( S)-6β, 11α 17-trihydroxy-6,20-epoxy- 1α, 7-olide-6, 7-seco-ent-kaur-15-one (2), 11α-dihydroxy-1α-acetoxy-7,20-olide-6,7-seco-ent-kaur-16-en-15-one (3) , 15(S)-3α, 17, 18-trihydroxy-ent-abieta-7(8)-en-15, 16-acetonide (4), 15( R)-3α, 17, 18-trihydroxy-ent-abieta- 7(8)-en-15,16-acetonide (5) , and named maoyecrystals C-E, G and H, respectively. The 13C NMR data of lasiokaurin (13) is reported in this paper for the first time.
|Journal||Chinese Journal of Natural Medicines|
|Publication status||Published - May 2003|
- Isodon japomcus
- Maoyecrystals C-E, G and H