Diterpenoids from Isodon adenantha

Bei Jiang; Hui Yang; Ma Lin Li; Ai Jun Hou; Quan Bin Han; Su Jun Wang; Sheng Hong Li; Han Dong Sun

doi:10.1021/np020084k

Diterpenoids from Isodon adenantha

Bei Jiang, Hui Yang, Ma Lin Li, Ai Jun Hou, Quan Bin Han, Su Jun Wang, Sheng Hong Li, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

30 Citations (Scopus)

Abstract

Eleven new diterpenoids, adenanthins B-L (1-11), together with five known analogues, calcicolin B (12), adenanthin (13), weisiensin A (14), nervosanin (15), and forrestin C (16), were isolated from the aerial parts of Isodon adenantha. The structures of 1-11 were elucidated on the basis of spectral methods, as well as the X-ray crystallographic analysis of 11. Compounds 2, 5, and 14 showed significant inhibitory activities against K562 cells, with IC₅₀ values less than 4.0 μg/mL, respectively.

Original language	English
Pages (from-to)	1111-1116
Number of pages	6
Journal	Journal of Natural Products
Volume	65
Issue number	8
Early online date	10 Jul 2002
DOIs	https://doi.org/10.1021/np020084k
Publication status	Published - 1 Aug 2002

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np020084k

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@article{83ab54fe9aea4356a697207b8dd97295,

title = "Diterpenoids from Isodon adenantha",

abstract = "Eleven new diterpenoids, adenanthins B-L (1-11), together with five known analogues, calcicolin B (12), adenanthin (13), weisiensin A (14), nervosanin (15), and forrestin C (16), were isolated from the aerial parts of Isodon adenantha. The structures of 1-11 were elucidated on the basis of spectral methods, as well as the X-ray crystallographic analysis of 11. Compounds 2, 5, and 14 showed significant inhibitory activities against K562 cells, with IC50 values less than 4.0 μg/mL, respectively.",

author = "Bei Jiang and Hui Yang and Li, {Ma Lin} and Hou, {Ai Jun} and Han, {Quan Bin} and Wang, {Su Jun} and Li, {Sheng Hong} and Sun, {Han Dong}",

year = "2002",

month = aug,

day = "1",

doi = "10.1021/np020084k",

language = "English",

volume = "65",

pages = "1111--1116",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Diterpenoids from Isodon adenantha

AU - Jiang, Bei

AU - Yang, Hui

AU - Li, Ma Lin

AU - Hou, Ai Jun

AU - Han, Quan Bin

AU - Wang, Su Jun

AU - Li, Sheng Hong

AU - Sun, Han Dong

PY - 2002/8/1

Y1 - 2002/8/1

N2 - Eleven new diterpenoids, adenanthins B-L (1-11), together with five known analogues, calcicolin B (12), adenanthin (13), weisiensin A (14), nervosanin (15), and forrestin C (16), were isolated from the aerial parts of Isodon adenantha. The structures of 1-11 were elucidated on the basis of spectral methods, as well as the X-ray crystallographic analysis of 11. Compounds 2, 5, and 14 showed significant inhibitory activities against K562 cells, with IC50 values less than 4.0 μg/mL, respectively.

AB - Eleven new diterpenoids, adenanthins B-L (1-11), together with five known analogues, calcicolin B (12), adenanthin (13), weisiensin A (14), nervosanin (15), and forrestin C (16), were isolated from the aerial parts of Isodon adenantha. The structures of 1-11 were elucidated on the basis of spectral methods, as well as the X-ray crystallographic analysis of 11. Compounds 2, 5, and 14 showed significant inhibitory activities against K562 cells, with IC50 values less than 4.0 μg/mL, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0036691253&partnerID=8YFLogxK

U2 - 10.1021/np020084k

DO - 10.1021/np020084k

M3 - Journal article

SN - 0163-3864

VL - 65

SP - 1111

EP - 1116

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 8

ER -

Diterpenoids from Isodon adenantha

Abstract

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