Diterpenoids from Isodon adenantha

Bei Jiang, Hui Yang, Ma Lin Li, Ai Jun Hou, Quan Bin Han, Su Jun Wang, Sheng Hong Li, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

30 Citations (Scopus)


Eleven new diterpenoids, adenanthins B-L (1-11), together with five known analogues, calcicolin B (12), adenanthin (13), weisiensin A (14), nervosanin (15), and forrestin C (16), were isolated from the aerial parts of Isodon adenantha. The structures of 1-11 were elucidated on the basis of spectral methods, as well as the X-ray crystallographic analysis of 11. Compounds 2, 5, and 14 showed significant inhibitory activities against K562 cells, with IC50 values less than 4.0 μg/mL, respectively.

Original languageEnglish
Pages (from-to)1111-1116
Number of pages6
JournalJournal of Natural Products
Issue number8
Early online date10 Jul 2002
Publication statusPublished - 1 Aug 2002

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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