Dissecting ancestry genomic background in substance dependence genome-wide association studies

Renato Polimanti; Can YANG; Hongyu Zhao; Joel Gelernter

doi:10.2217/pgs.15.91

Dissecting ancestry genomic background in substance dependence genome-wide association studies

Renato Polimanti, Can YANG, Hongyu Zhao, Joel Gelernter^*

^*Corresponding author for this work

Department of Mathematics

Research output: Contribution to journal › Journal article › peer-review

20 Citations (Scopus)

Abstract

Aims: To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. Materials & methods: We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes. Results: We observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes. Conclusion: Population differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.

Original language	English
Pages (from-to)	1487-1498
Number of pages	12
Journal	Pharmacogenomics
Volume	16
Issue number	13
DOIs	https://doi.org/10.2217/pgs.15.91
Publication status	Published - 1 Aug 2015

Scopus Subject Areas

Molecular Medicine
Genetics
Pharmacology

User-Defined Keywords

African-Americans
ethnicity
European-Americans
substance dependence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/pgs.15.91

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title = "Dissecting ancestry genomic background in substance dependence genome-wide association studies",

abstract = "Aims: To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. Materials & methods: We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes. Results: We observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes. Conclusion: Population differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.",

keywords = "African-Americans, ethnicity, European-Americans, substance dependence",

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T1 - Dissecting ancestry genomic background in substance dependence genome-wide association studies

AU - Polimanti, Renato

AU - YANG, Can

AU - Zhao, Hongyu

AU - Gelernter, Joel

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Aims: To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. Materials & methods: We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes. Results: We observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes. Conclusion: Population differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.

AB - Aims: To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. Materials & methods: We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes. Results: We observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes. Conclusion: Population differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.

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JO - Pharmacogenomics

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Dissecting ancestry genomic background in substance dependence genome-wide association studies

Abstract

Scopus Subject Areas

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