Dissecting ancestry genomic background in substance dependence genome-wide association studies

Renato Polimanti, Can YANG, Hongyu Zhao, Joel Gelernter*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Aims: To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. Materials & methods: We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes. Results: We observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes. Conclusion: Population differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.

Original languageEnglish
Pages (from-to)1487-1498
Number of pages12
JournalPharmacogenomics
Volume16
Issue number13
DOIs
Publication statusPublished - 1 Aug 2015

Scopus Subject Areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

User-Defined Keywords

  • African-Americans
  • ethnicity
  • European-Americans
  • substance dependence

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