Disrupted thalamic resting-state functional networks in schizophrenia

Hsiao Lan Sharon Wang, Chi Lun Rau, Yu Mei Li, Ya Ping Chen, Rongjun Yu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

52 Citations (Scopus)


The thalamus plays a key role in filtering or gating information and has extensive interconnectivity with other brain regions. Recent studies provide evidence of thalamus abnormality in schizophrenia, but the resting functional networks of the thalamus in schizophrenia is still unclear. We characterize the thalamic resting-state networks (RSNs) in 72 patients with schizophrenia and 73 healthy controls, using a standard seedbased whole-brain correlation. In comparison with controls, patients exhibited enhance thalamic connectivity with bilateral precentral gyrus, dorsal medial frontal gyrus, middle occipital gyrus, and lingual gyrus. Reduced thalamic connectivity in schizophrenia was found in bilateral superior frontal gyrus, anterior cingualte cortex, inferior parietal lobe, and cerebellum. Our findings question the “disconnectivity model” of schizophrenia by showing the over-connected thalamic network during resting state in schizophrenia and highlight the thalamus as a key hub in the schizophrenic network abnormality.

Original languageEnglish
Article number45
Number of pages9
JournalFrontiers in Behavioral Neuroscience
Publication statusPublished - 25 Feb 2015

Scopus Subject Areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

User-Defined Keywords

  • fMRI
  • Functional connectivity
  • Resting-state
  • Schizophrenia
  • Thalamus


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